Highlights
- •APT imaging is a usefulness method without the need for contrast enhancement.
- •Triple negative and high-Ki-67 breast cancers show high APT signal intensity.
- •APT imaging helps clinicians to assess biological status of breast cancers.
Abstract
Purpose
To assess the usefulness of amide proton transfer (APT) imaging to predict the biological
status of breast cancers.
Method
Sixty-six patients (age range 31–85 years, mean 58.9 years) with histopathologically
proven invasive ductal carcinomas of 2 cm or larger in diameter were included in this
study. 3D APT weighted imaging was conducted on a 3 T scanner. Mean APT signal intensity
(SI) was analyzed in relation to biological subtypes, Ki-67 labeling index, and nuclear
grades (NGs).
Results
The triple-negative (TN) cancers (n = 10; 2.75 ± 0.42%) showed significantly higher
APT SI than the luminal type cancers (n = 48; 1.74 ± 0.83) and HER2 cancers (n = 8;
1.83 ± 0.21) (P = 0.0007, 0.03). APT SI had weakly positive correlation with the Ki-67
labeling index (r = 0.38, P = 0.002). The mean APT SIs were significantly higher for
high-Ki-67 (>30%) (n = 31; 2.25 ± 0.70) than low-Ki-67 (≤30%) cancers (n = 35; 1.60 ± 0.79)
(P = 0.0007). There was no significant difference in the APT SIs between NG 1–2 (n = 31;
1.71 ± 0.84) and NG 3 (n = 35; 2.08 ± 0.76%) cancers (P = 0.06).
Conclusions
TN and high-Ki-67 breast cancers showed high APT SIs. APT imaging can help to predict
the biological status of breast cancers.
Keywords
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Article info
Publication history
Published online: February 08, 2023
Accepted:
February 2,
2023
Received in revised form:
January 12,
2023
Received:
October 13,
2022
Identification
Copyright
© 2023 Elsevier Inc. All rights reserved.
