Highlights
- •We demonstrated the prognostic role of 18F-FDG PET/CT in stage I and II NSCLC
- •SUVmax, SUVmean, SUVlbm, SUVbsa and S-L were demonstrated as independent prognostic factors for OS and DSS.
- •18F-FDG PET/CT semiquantitative parameters were independent prognosticators for DSS in patients treated with surgery and adjuvant therapy.
Abstract
Objective
investigate the prognostic role of baseline 18F-FDG PET/CT in stage I-II NSCLC.
Material and methods
296 patients were included. Clinicopathological features and PET/CT semiquantitative
parameters [standardized uptake value (SUV) body weight max (SUVmax), SUV body weight
mean (SUVmean), SUV lean body mass (SUVlbm), SUV body surface area (SUVbsa), metabolic
tumor volume (MTV), total lesion glycolysis (TLG), ratio SUVmax/liver (S-L) and ratio
SUVmax/blood-pool (S-BP) were extracted]. Anova and Kruskall-Wallis tests were used
to assess the relationship between these parameters. Kaplan-Meier, univariate and
multivariate analysis were performed to search independent prognostic factors for
progression free (PFS), overall survival (OS) and disease specific survival (DSS).
Results
Correlation between PET/CT semiquantitative parameters and histology, stage, size,
grading and presence of nodal metastasis were reported. Mean PFS was 28.1 months,
relapse/progression of disease occurred in 85 patients (28.7%). Mean OS was 33.3 months,
death occurred in 43 patients (14.5%); specific death by NSCLC occurred in 26 subjects
(8.8%). Kaplan-Meier analyses revealed most of semiquantitative parameters as predictive
for PFS, OS and DSS. For DSS, this was confirmed when dividing between patients with
surgery and surgery with other therapies. SUVmax, SUVmean, SUVlbm, SUVbsa and S-L
revealed to be independent prognosticators for OS and DSS. S-BP was an independent
prognosticator for DSS. SUVmax, SUVmean, SUVlbm, S-L and S-BP were confirmed as independent
prognosticators for DSS in the group of patients treated with surgery and subsequent
adjuvant therapy.
Conclusion
Baseline 18F-FDG PET/CT semiquantitative parameters are confirmed as prognostic tools for stage
I-II NSCLC, in particular for DSS.
Keywords
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Article info
Publication history
Published online: December 01, 2022
Accepted:
November 17,
2022
Received in revised form:
November 14,
2022
Received:
June 4,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
