Advertisement

Hidradenocarcinoma: a rare but challenging diagnosis

  • Jhanna A. Moore
    Correspondence
    Corresponding author at: Icahn School of Medicine at Mount Sinai West, 1000 10th Avenue, New York, NY 10019, United States of America.
    Affiliations
    Departments of Pathology (S.C.), Surgery (S.K., D.L.) and Radiology (J.A.M., A.K.), Icahn School of Medicine at Mount Sinai West Hospital, 1000 10th Avenue, New York, NY, 10019, United States of America
    Search for articles by this author
  • Shengjie Cui
    Affiliations
    Departments of Pathology (S.C.), Surgery (S.K., D.L.) and Radiology (J.A.M., A.K.), Icahn School of Medicine at Mount Sinai West Hospital, 1000 10th Avenue, New York, NY, 10019, United States of America
    Search for articles by this author
  • Natalie Berger
    Affiliations
    Student at Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029, United States of America
    Search for articles by this author
  • Sun Kim
    Affiliations
    Departments of Pathology (S.C.), Surgery (S.K., D.L.) and Radiology (J.A.M., A.K.), Icahn School of Medicine at Mount Sinai West Hospital, 1000 10th Avenue, New York, NY, 10019, United States of America
    Search for articles by this author
  • Devon O'Guinn
    Affiliations
    Departments of Pathology (S.C.), Surgery (S.K., D.L.) and Radiology (J.A.M., A.K.), Icahn School of Medicine at Mount Sinai West Hospital, 1000 10th Avenue, New York, NY, 10019, United States of America
    Search for articles by this author
  • Daniel Labow
    Affiliations
    Departments of Pathology (S.C.), Surgery (S.K., D.L.) and Radiology (J.A.M., A.K.), Icahn School of Medicine at Mount Sinai West Hospital, 1000 10th Avenue, New York, NY, 10019, United States of America
    Search for articles by this author
  • Amita Kamath
    Affiliations
    Departments of Pathology (S.C.), Surgery (S.K., D.L.) and Radiology (J.A.M., A.K.), Icahn School of Medicine at Mount Sinai West Hospital, 1000 10th Avenue, New York, NY, 10019, United States of America
    Search for articles by this author
Published:February 01, 2021DOI:https://doi.org/10.1016/j.clinimag.2021.01.024

      Highlights

      • Hidradenocarcinoma poses a diagnostic challenge in differentiating it from its benign counterpart, hidradenoma.
      • Specific MRI signs in this novel case report helped facilitate an accurate diagnosis of hidradenocarcinoma.
      • MRI has a potential role for improving the diagnostic accuracy of hidradenocarcinoma.

      Abstract

      Hidradenocarcinoma is a rare, aggressive cancer arising from sweat glands. Hidradenocarcinoma has no definitive histologic features compared to its benign hidradenoma, thereby posing a diagnostic challenge for clinicians and pathologists. This novel case report demonstrates specific MRI signs that suggested malignant degeneration of hidradenoma.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Clinical Imaging
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Mir khan B.
        • Mansha M.
        • Ali N.
        • et al.
        Hidradenocarcinoma: five years of local and systemic control of a rare sweat gland neoplasm with nodal metastasis.
        Cureus. 2018; 10e2884https://doi.org/10.7759/cureus.2884
        • Gauerke S.
        • Driscoll J.J.
        Hidradenocarcinoma: a brief review and future directions.
        Arch Pathol Lab Med. 2010; 134: 781-785https://doi.org/10.1043/1543-2165-134.5.781
        • Soni Abhishek
        • et al.
        Current management approach to hidradenocarcinoma: a comprehensive review of the literature.
        Ecancermedicalscience. 19 Mar. 2015; 9 517https://doi.org/10.3332/ecancer.2015.517
        • Johnson E.P.
        • Keyes J.
        • Zayat V.
        • et al.
        Malignant Hidradenocarcinoma of the Axilla.
        Cureus. 24 Feb 2020; 12e7091https://doi.org/10.7759/cureus.7091
        • Guillot B.
        Belkacemi Y. Mirimanoff R. Ozsahin M. From Unusual Cutaneous Malignancies: Cutaneous Adnexal Tumors in Management of Rare Adult Tumors. Springer- Verlag France, Paris2009: 471-477https://doi.org/10.1007/978-2-287-92246-6_53
        • Delgado R.
        • Kraus D.
        • Coit D.G.
        • Busam K.J.
        Sentinel lymph node analysis in patients with sweat gland carcinoma.
        Cancer. 2003; 97: 2279-2284https://doi.org/10.1002/cncr.11327
        • Bogner P.N.
        • Fullen D.R.
        • Lowe L.
        • et al.
        Lymphatic mapping and sentinel lymph node biopsy in the detection of early metastasis from sweat gland carcinoma.
        Cancer. 2003; 97: 2285-2289https://doi.org/10.1002/cncr.11328
        • Gandhi D.
        • Ahuja K.
        • Nepal P.
        • Sawhney H.
        • Sharma P.
        • Kier R.
        Clear cell hidradenoma of the foot: a case report with literature review.
        AME Med J. 2020; 5: 33