Highlights
- •This meta-analysis indicated that magnetic resonance hysterosalpingography (MR-HSG) had high sensitivity and specificity relative to the imaging standard X-HSG for fallopian tubal occlusion in the context of female infertility.
- •Both the viscosity of contrast agent and the test order affected the accuracy of MR-HSG for evaluating tubal occlusion.
- •Blind method application, thickness, magnetic intensity and interval between X-HSG and MR-HSG may affect the results of MR-HSG.
Abstract
Objective
To evaluate the diagnostic performance of magnetic resonance hysterosalpingography
for fallopian tubal occlusion in the context of female infertility when compared to
the diagnostic performance of conditional X-ray hysterosalpingography.
Methods
PubMed, EMBASE, Web of Science, EBSCO, Cochrane Library database, Scopus were searched
for studies in which magnetic resonance hysterosalpingography and X-ray hysterosalpingography
were used as diagnostic tools for tubal occlusion assessment; databases were searched
through April 2020. Two researchers conducted study inclusion assessment, data extraction,
a systematic review, and pooled meta-analysis independently. Stata 15.1 software was
used to analyze the pooled sensitivity, specificity, diagnostic odds ratio, positive
and negative likelihood ratios, and the area under the summary receiver-operating
characteristic curve of magnetic resonance hysterosalpingography.
Results
A total of five studies involving 101 patients and 198 fallopian tubes were finally
included. Compared with the conditional X-ray hysterosalpingography (the imaging gold
standard), the pooled sensitivity, specificity, positive likelihood ratio, negative
likelihood ratio, diagnostic odds ratio and the area under the curve of magnetic resonance
hysterosalpingography for tubal occlusion were 0.91 (95% CI: 0.48–0.99), 1.00 (95%
CI: 0.87–1.00), 230.47 (95% CI: 6.79–7824.72), 0.09 (95% CI: 0.01–0.80), 2676.10 (95%
CI: 61.35–120,000), and 1.00 (95% CI: 0.99–1.00), respectively. Subgroup analyses
revealed that viscosity of contrast agent (P = 0.024) and test order (P = 0.036) affected the accuracy of MR-HSG to evaluate tubal occlusion.
Conclusions
Our meta-analysis indicated magnetic resonance hysterosalpingography may serve as
an alternative for further evaluation of fallopian tubal occlusion of female infertility.
Keywords
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Article info
Publication history
Published online: November 05, 2020
Accepted:
November 2,
2020
Received in revised form:
October 27,
2020
Received:
January 23,
2020
Footnotes
☆This work was supported by Gansu Province Science Foundation for Youths [18JR3RA039] and Lanzhou Science and Technology Development Guidance Plan Project [2017-ZD-33].
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
