Abstract
Purpose
The present study was carried out to investigate any possible linkage between cerebral
grey matter volumetric, iron changes, white matter's lesions load and serum iron levels
in a group of relapsing-remitting multiple sclerosis (RRMS) patients.
Materials and methods
Sixty-five RRMS patients along with thirty-four age-matched healthy controls (HCs)
were recruited. Serum samples were isolated from blood samples which were collected
in vacutainer plain tubes individually from both groups. Both groups were scanned
at 1.5 T magnetic resonance imaging (MRI) using the following 3D sequences; T1-weighted
gradient echo (MPRAGE), T2*-weighted gradient echo and T2-weighted fluid-attenuated
inversion recovery (FLAIR).
Results
Significant differences were observed between the RRMS patients and HCs for cortical
and deep grey matter (dGM) volumes where cortical and dGM volumes in RRMS patient
were significantly smaller than those in HCs. While iron deposition in the cortex,
putamen (PT) and globus pallidus (GP) of RRMS patients were significantly higher than
those of HCs, iron levels in thalamus (TH) and serum were significantly lower in RRMS
compared to those in HCs. Except for T2 lesion load, none of volumetric measures showed
any association with patients' disability status. Cerebral grey matter's iron changes
did not show any association with those of serum.
Conclusion
Smaller cortical and subcortical grey matter volumes in RRMS patients compared to
HCs were detected. None of the volumetric measures showed any association with patients'
disability status. RRMS patients showed increased iron levels in the PT, GP and cortex
and decreased levels in the TH and serum.
Keywords
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Article info
Publication history
Published online: September 19, 2020
Accepted:
September 11,
2020
Received in revised form:
August 17,
2020
Received:
June 25,
2020
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
