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Critical illness-associated cerebral microbleed in a patient with sickle cell disease: A case report and review of the literature

  • Author Footnotes
    1 These two authors contributed equally in this work.
    Omid Shafaat
    Footnotes
    1 These two authors contributed equally in this work.
    Affiliations
    The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA

    Department of Radiology and Interventional Neuroradiology, Isfahan University of Medical Sciences, Isfahan, Iran
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  • Author Footnotes
    1 These two authors contributed equally in this work.
    Houman Sotoudeh
    Correspondence
    Corresponding author: Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham (UAB), 619 19th St S, JT N 333, Birmingham, AL 35294, USA.
    Footnotes
    1 These two authors contributed equally in this work.
    Affiliations
    Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, 619 19th St S, Birmingham, AL 35294, USA
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  • Alireza Zandifar
    Affiliations
    Department of Neurology and Interventional Neuroradiology, Isfahan University of Medical Sciences, Isfahan, Iran
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  • Philip R. Chapman
    Affiliations
    Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, 619 19th St S, Birmingham, AL 35294, USA
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  • Glenn H. Roberson
    Affiliations
    Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, 619 19th St S, Birmingham, AL 35294, USA
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  • Ehsan Sotoudeh
    Affiliations
    Department of Surgery, Red Crescent Iranian Hospital in Dubai, P.O.BOX: 2330, Al-Wasl Road, Dubai 2330, United Arab Emirates
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  • Aparna Singhal
    Affiliations
    Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, 619 19th St S, Birmingham, AL 35294, USA
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  • Author Footnotes
    1 These two authors contributed equally in this work.

      Highlights

      • CICM is a relatively rare and newly described form of cerebral microhemorrhage.
      • CICM can occur in sickle cell disease patients.
      • CICM mainly involves the gray-white matter junction of the brain.

      Abstract

      Critical illness–associated cerebral microbleed (CICM) is a relatively rare and newly described condition. It can occur in critically ill ICU patients and can be secondary to many underlying etiologies. CICM is associated with high mortality and permanent neurologic deficits in surviving patients. Distribution of cerebral microhemorrhages in neuroimaging findings is critical for accurate diagnosis of this condition.
      Here, we present an ICU admitted patient with sickle cell disease crisis and CICM and will discuss their clinically and radiologically distinct phenomenon followed by a review of current literature.

      Keywords

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