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Pleomorphic xanthoastrocytoma in the posterior fossa: a case report with advanced neuroimaging findings

Published:February 25, 2020DOI:https://doi.org/10.1016/j.clinimag.2020.02.010

      Highlights

      • Infratentorial PXAs may follow the conventional imaging characteristics of those located in the supratentorial compartment
      • Advanced MRI features of infratentorial PXAs follow the same rules for grade discrimination used in other astrocytic tumors
      • Infratentorial non-restricting periventricular solid-cystic lesion in a young patient should raise suspicion for PXA

      Abstract

      Pleomorphic xanthoastrocytoma (PXA) is a rare glioma usually occurring in children and young adults. It is a benign World Health Organization (WHO) grade II tumor that accounts for <1% of all astrocytomas. Its occurrence in the infratentorial compartment is rare, and the cerebellum is the most common of the unusual locations. Few case reports have described conventional imaging features of these tumors, but none has reported the advanced magnetic resonance (MR) neuroimaging features in dynamic susceptibility perfusion-weighted imaging (DSC-PWI), diffusion weighted-imaging (DWI) and MR spectroscopy. Therefore, the purpose of this study is to report a case of PXA in the cerebellum of a 28-year-old patient and discuss the MR advanced imaging characteristics compared to the more common PXA supratentorial type.

      Abbreviations:

      PXA (pleomorphic xanthoastrocytoma), DSC-PWI (dynamic susceptibility perfusion-weighted imaging), DWI (diffusion weighted-imaging), MRI (magnetic resonance imaging), CT (Computed tomography), WHO (World Health Organization), FLAIR (Fluid attenuation inversion recovery), NAA (N-acetylaspartate), ADC (apparent diffusion coefficient), GFAP (Glial fibrillary acidic protein), CBV (cerebral blood volume), IDH1 (isocitrate dehydrogenase 1)

      Keywords

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