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Elevated prevalence of moderate-to-severe hepatic steatosis in World Trade Center General Responder Cohort in a program of CT lung screening

Published:December 12, 2019DOI:https://doi.org/10.1016/j.clinimag.2019.12.009

      Highlights

      • LDCT images can provide important information about hepatic steatosis non-invasively and at no additional cost.
      • Individuals with liver attenuation < 40HU on LDCT should be advised of the high likelihood of having excess liver fat.
      • Patients with liver attenuation < 40HU should contact their referring physician or a liver specialist for further work up.

      Abstract

      Background and aims

      To determine the prevalence of moderate-to-severe hepatic steatosis (HS) and associated risk factors in members of the World Trade Center (WTC) General Responder Cohort (GRC) who qualify for low-dose non-contrast computed tomography for lung cancer screening and compare them to non-WTC participants in the same screening program.

      Methods

      All participants gave written informed consent before participating in this IRB-approved study. Clinical variables and laboratory values were recorded. Hepatic attenuation measurement (Hounsfield unit; HU) was measured on low-dose computed tomography (LDCT) and a threshold attenuation value <40HU indicated moderate-to-severe HS. Bivariate and multivariable linear and logistic regression analyses were performed. Propensity scores (PS) were calculated and inverse probability weighting (IPW) was used to adjust for potential confounders when comparing the WTC with non-WTC participants.

      Results

      The prevalence of moderate-to-severe HS was 16.2% among 154 WTC participants compared to 5.3% among 170 non-WTC participants. In WTC members, moderate-to-severe HS was associated with higher BMI, higher laboratory liver function tests, and former smoking status. Using PS analysis and IPW to account for potential confounders, the odds ratio for moderate-to-severe HS was 3.4-fold higher (95% confidence interval: 1.7–6.7) in the WTC participants compared with non-WTC participants. Moderate-to-severe HS was also associated with higher BMI and former smoker status.

      Conclusion

      Prevalence of moderate-to-severe HS was >3-fold higher in the WTC-GRC group than in other participants.

      Keywords

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