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Correlation between hyperhemoglobinemia and pseudosubarachnoid hemorrhage

Published:September 12, 2019DOI:https://doi.org/10.1016/j.clinimag.2019.09.002

      Highlights

      • Hyperhemoglobinemia may be a contributing factor to pseudo-SAH.
      • We analyzed the incidence of pseudo-SAH in hyperhemoglobinemia patients.
      • We retrospectively analyzed pseudo-SAH on CT associated with hyperhemoglobinemia.

      Abstract

      Background and purpose

      Subarachnoid hemorrhage (SAH) is a severe cerebrovascular condition. Some cases present with typical signs of SAH on head computed tomography (CT), whereas other cases have a condition known as pseudo-SAH, with no bleeding actually present. In our clinical experience, we noted that cases of hyperhemoglobinemia often also had pseudo-SAH. Here we investigated the relationship between hyperhemoglobinemia and pseudo-SAH and explored the underlying mechanism.

      Methods

      We retrospectively collected data for patients who were treated for hyperhemoglobinemia in our hospital and had available brain CT scans. An age-matched control group of patients with normal hemoglobin levels was used to compare the incidence of pseudo-SAH between individuals with elevated versus normal hemoglobin levels. Spearman correlation and logistic regression analyses were performed to identify correlations between pseudo-SAH and hemoglobin level as well as gender, history of chronic obstructive pulmonary disease, and smoking history.

      Results

      The incidence of pseudo-SAH was significantly higher in hyperhemoglobinemia group than in the control group (12.5% vs. 1.6%, respectively, P < 0.001), and within the hyperhemoglobinemia group, it was significantly higher among those with a hemoglobin value ≥210 g/L than among those with a hemoglobin value <210 g/L (29.2% vs. 8.8%, respectively, P < 0.001). Spearman correlation analysis and logistic regression analysis showed a significant correlation between pseudo-SAH and hyperhemoglobinemia but no significant correlation between pseudo-SAH and gender, COPD, or smoking history.

      Conclusion

      Hyperhemoglobinemia may be a contributing factor to pseudo-SAH. Clinicians should be aware of this phenomenon and be careful to distinguish pseudo-SAH from SAH, particularly in patients with hyperhemoglobinemia.

      Keywords

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