Highlights
- •Reference values for the LV WT and other wall motion parameters obtained on CT-MPI are presented in this article
- •WT was higher in septal wall and basal-level, and significantly associated with age, height, weight, BMI, and blood pressure
- •SWT was highest in lateral and apical myocardium, while lateral and basal myocardium exhibited the greatest WM
- •Knowledge of such normal reference measurements could provide additional beneficial information during CT-MPI interpretations
Abstract
Purpose
To use adenosine-induced stress CT myocardial perfusion imaging (CT-MPI) to determine
normal reference values for left ventricle (LV) wall thickness (WT) and motion parameters.
Methods
This study included 106 Korean subjects (52 men and 54 women) who underwent CT-MPI
due to chest pain, but were not found to have any detectable mild or severe coronary
artery disease or myocardial perfusion defect. The following quantitative parameters
were assessed on the CT-MPI according to a 17-segment model: LV myocardial thickness
at end-systolic (WTES) and end-diastolic (WTED) phases, systolic wall thickening (SWT), and wall motion (WM). The associations of
the measured parameters with the subjects' demographic characteristics and comorbidities
were also analyzed.
Results
Septal wall (7.2 mm) and basal-level (7.7 mm) LV myocardium demonstrated significantly
higher WT (p < 0.001). SWT was highest in lateral (77.8%, p < 0.014) and apical (78.9%,
p = 0.009) myocardium, while lateral (7.7 mm) and basal (6.7 mm) myocardium exhibited
the greatest WM (p < 0.001). WT was significantly higher in men and younger (<60 years)
subjects (all, p < 0.001). Hypertensive individuals presented with significantly higher
SWT (79.9%, p = 0.024). LV WT exhibited statistically significant correlations (all
positive, except for age) with age, height, weight, body surface area, body mass index,
and systolic blood pressure (all, p < 0.010).
Conclusions
The present study provides CT-MPI reference values for LV myocardial WT, SWT, and
WM measured on an adult Korean population. Knowledge of such normal reference measurements
would be beneficial for the efficient interpretation of CT-MPI examinations in populations
of Asian ethnicity.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Global and regional patterns in cardiovascular mortality from 1990 to 2013.Circulation. 2015; 132: 1667-1678
- Comparison of coronary computed tomography angiography-derived vs invasive fractional flow reserve assessment: meta-analysis with subgroup evaluation of intermediate stenosis.Acad Radiol. 2016; 23: 1402-1411
- Association between C-reactive protein and type of coronary arterial plaque in asymptomatic patients: assessment with coronary CT angiography.Radiology. 2014; 272: 665-673
- Left ventricular function can reliably be assessed from dual-source CT using ECG-gated tube current modulation.Invest Radiol. 2009; 44: 384-389
- Coronary CT angiography characteristics of OCT-defined thin-cap fibroatheroma: a section-to-section comparison study.Eur Radiol. 2018; 28: 833-843
- Analysis of ventricular function by CT.J Cardiovasc Comput Tomogr. 2015; 9: 1-12
- Quantitative assessment of left ventricular function with dual-source CT in comparison to cardiac magnetic resonance imaging: initial findings.Eur Radiol. 2008; 18: 570-575
- Cardiac functional analysis with multi-detector row CT and segmental reconstruction algorithm: comparison with echocardiography, SPECT, and MR imaging.Radiology. 2005; 234: 381-390
- Assessment of left ventricular ejection fraction and regional wall motion with 64-slice multidetector CT: a comparison with two-dimensional transthoracic echocardiography.Br J Radiol. 2010; 83: 28-34
- CT myocardial perfusion imaging: current status and future perspectives.Int J Cardiovasc Imaging. 2017; 33: 1009-1020
- Left ventricular function studied with MDCT.Eur Radiol. 2006; 16: 342-357
- Cardiovascular function in multi-ethnic study of atherosclerosis: normal values by age, sex, and ethnicity.AJR Am J Roentgenol. 2006; 186: S357-S365
- Sex-specific normalized reference values of heart and great vessel dimensions in cardiac CT angiography.AJR Am J Roentgenol. 2011; 196: 788-794
- Multimodality appropriate use criteria for noninvasive cardiac imaging: expert consensus of the Asian Society of Cardiovascular Imaging.Korean J Radiol. 2017; 18 (2017): 871-880
- Stress myocardial perfusion CT in patients suspected of having coronary artery disease: visual and quantitative analysis-validation by using fractional flow reserve.Radiology. 2015; 276: 715-723
- Geometric predictors of left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy: a 3D computed tomography analysis.Eur Heart J Cardiovasc Imaging. 2018; 19: 1149-1156
- Echocardiographic assessment of myocardial ischemia.Ann Transl Med. 2016; 4: 259
- Evaluation of left ventricular diastolic function with cardiac MR imaging.Radiographics. 2011; 31: 239-259
- Comprehensive assessment of myocardial perfusion defects, regional wall motion, and left ventricular function by using 64-section multidetector CT.Radiology. 2008; 248: 466-475
- Diagnostic performance of on-site CT-derived fractional flow reserve versus CT perfusion.Eur Heart J Cardiovasc Imaging. 2017; 18: 432-440
- Left ventricular functional parameters and geometric patterns in korean adults on coronary CT angiography with a 320-detector-row CT scanner.Korean J Radiol. 2017; 18: 664-673
- Normal left ventricular myocardial thickness for middle-aged and older subjects with steady-state free precession cardiac magnetic resonance: the multi-ethnic study of atherosclerosis.Circ Cardiovasc Imaging. 2012; 5: 500-508
- Assessment of left and right ventricular parameters in healthy Korean volunteers using cardiac magnetic resonance imaging: change in ventricular volume and function based on age, gender and body surface area.Int J Cardiovasc Imaging. 2012; 28: 141-147
- Regional thicknesses and thickening of compacted and trabeculated myocardial layers of the normal left ventricle studied by cardiovascular magnetic resonance.Circ Cardiovasc Imaging. 2011; 4: 139-146
- Cardiac morphology and function reference values derived from a large subset of healthy young Caucasian adults by magnetic resonance imaging.Eur Heart J Cardiovasc Imaging. 2016; 17: 981-990
- Reference values for quantitative left ventricular and left atrial measurements in cardiac computed tomography.Eur Radiol. 2008; 18: 1625-1634
- Quantitative assessment of left ventricular systolic wall thickening using multidetector computed tomography.Eur J Radiol. 2009; 72: 92-97
- Correction of left ventricular wall thickening from short-axis cine MRI for basal-descent through-plane motion.J Magn Reson Imaging. 2011; 33: 464-473
- Quantitative assessment of regional left ventricular wall thickness and thickening using 16 multidetector-row computed tomography: comparison with cine magnetic resonance imaging.Radiat Med. 2007; 25: 119-126
- Normal values for cardiovascular magnetic resonance in adults and children.J Cardiovasc Magn Reson. 2015; 17: 29
Article info
Publication history
Published online: April 12, 2019
Accepted:
April 9,
2019
Received in revised form:
February 11,
2019
Received:
June 13,
2018
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
