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Reference parameters for left ventricular wall thickness, thickening, and motion in stress myocardial perfusion CT: Global and regional assessment

  • Young Hoon Cho
    Affiliations
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
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  • Joon-Won Kang
    Correspondence
    Corresponding author at: Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
    Affiliations
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
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  • Seong Hoon Choi
    Affiliations
    Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine, Banguhjin-ro 877, Dong-gui, Ulsan, Republic of Korea
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  • Dong Hyun Yang
    Affiliations
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
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  • Tran Thi Xuan Anh
    Affiliations
    Department of Cardiology, University Medical Center, 215 Hồng Bàng, phường 11, Quận 5, Hồ Chí Minh, Viet Nam
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  • Eun-Seok Shin
    Affiliations
    Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Banguhjin-ro 877, Dong-gui, Ulsan, Republic of Korea
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  • Young-Hak Kim
    Affiliations
    Department of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
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      Highlights

      • Reference values for the LV WT and other wall motion parameters obtained on CT-MPI are presented in this article
      • WT was higher in septal wall and basal-level, and significantly associated with age, height, weight, BMI, and blood pressure
      • SWT was highest in lateral and apical myocardium, while lateral and basal myocardium exhibited the greatest WM
      • Knowledge of such normal reference measurements could provide additional beneficial information during CT-MPI interpretations

      Abstract

      Purpose

      To use adenosine-induced stress CT myocardial perfusion imaging (CT-MPI) to determine normal reference values for left ventricle (LV) wall thickness (WT) and motion parameters.

      Methods

      This study included 106 Korean subjects (52 men and 54 women) who underwent CT-MPI due to chest pain, but were not found to have any detectable mild or severe coronary artery disease or myocardial perfusion defect. The following quantitative parameters were assessed on the CT-MPI according to a 17-segment model: LV myocardial thickness at end-systolic (WTES) and end-diastolic (WTED) phases, systolic wall thickening (SWT), and wall motion (WM). The associations of the measured parameters with the subjects' demographic characteristics and comorbidities were also analyzed.

      Results

      Septal wall (7.2 mm) and basal-level (7.7 mm) LV myocardium demonstrated significantly higher WT (p < 0.001). SWT was highest in lateral (77.8%, p < 0.014) and apical (78.9%, p = 0.009) myocardium, while lateral (7.7 mm) and basal (6.7 mm) myocardium exhibited the greatest WM (p < 0.001). WT was significantly higher in men and younger (<60 years) subjects (all, p < 0.001). Hypertensive individuals presented with significantly higher SWT (79.9%, p = 0.024). LV WT exhibited statistically significant correlations (all positive, except for age) with age, height, weight, body surface area, body mass index, and systolic blood pressure (all, p < 0.010).

      Conclusions

      The present study provides CT-MPI reference values for LV myocardial WT, SWT, and WM measured on an adult Korean population. Knowledge of such normal reference measurements would be beneficial for the efficient interpretation of CT-MPI examinations in populations of Asian ethnicity.

      Keywords

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