Highlights
- •Juvenile granulosa cell tumor (JGCT) is extremely rare in the general population, but it is a diagnosis that must be considered in patients with Maffucci syndrome and Ollier disease.
- •JGCT is hormonally sensitive and exhibit rapid growth during pregnancy, therefore, early diagnosis is vital.
- •Tumor markers have to be interpreted with caution during pregnancy. As a result, imaging plays an important role in the diagnosis of JGCT.
Abstract
Juvenile granulosa cell tumor (JGCT) is an extremely rare ovarian tumor that has been
associated with Maffucci syndrome. It both secretes hormone and has been postulated
to grow in response to hormone. We present a case of a 33-year-old G1P0 asymptomatic
woman with a history of Maffucci syndrome found to have a left adnexal mass on routine
ultrasonography at 13 weeks gestation. This case demonstrates the sonographic and
magnetic resonance imaging (MRI) features of JGCT, as well as the natural progression
of the tumor during pregnancy. A follow-up ultrasound 3 weeks after initial diagnosis
demonstrated marked growth in size and vascularity of the tumor, prompting unilateral
salpingo-oophorectomy. Histopathological findings confirmed the diagnosis of JGCT.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Early pregnancy complicated with juvenile granulosa cell tumor.Am J Med Sci. 2011; 342 (Nov 1): 435-437
- Juvenile granulosa cell tumor associated with pregnancy: report of a case and review of the literature.Gynecol Oncol. 2006; 100 (Feb 1): 426-429
- Functioning ovarian tumors: direct and indirect findings at MR imaging.Radiographics. 2004; 24 (Oct): S147-S166
- Genetics and genomics of ovarian sex cord-stromal tumors.Clin Genet. 2017; 91 (Feb 1): 285-291
- Juvenile granulosa cell tumor discovered during pregnancy: case report with immunohistochemical study of steroidogenesis.Pathol Int. 1997; 47 (May): 325-328
- Granulosa cell tumor of the ovary – an incidental finding during caesarean section.J Cases Obstet Gynecol. 2017; 4: 45-48
- Gynaecological malignancies in pregnancy.Rev Gynaecol Pract. 2004; 4 (Sep): 162-168
- Review of ovarian tumors in children and adolescents: radiologic-pathologic correlation.Radio Graphics. 2014 Nov 10; 34: 2039-2055
- Imaging of gynecological disease (3): clinical and ultrasound characteristics of granulosa cell tumors of the ovary.Ultrasound Obstet Gynecol. 2008; 31 (Apr 1): 450-456
- High-resolution sonographic findings of ovarian granulosa cell tumors.J Ultrasound Med. 2010; 29 (Feb 1): 187-193
Article info
Publication history
Published online: March 13, 2019
Accepted:
March 12,
2019
Received in revised form:
March 5,
2019
Received:
January 12,
2019
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
