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Evaluation of association between degree of background parenchymal enhancement on MRI and breast cancer subtype

      Highlights

      • No significant association was present between high BPE and Luminal B, HER2+ or basal subtypes of breast tumor.
      • No significant association between high BPE and axillary nodal disease, high grade tumors, high Ki-67 or larger tumors.
      • Patients with high BPE may be at increased risk for breast cancer but not necessarily for those with a poor prognosis.

      Abstract

      Purpose

      Evaluate possible association between BPE and breast cancer tumor type/prognostic markers.

      Methods

      IRB approved retrospective study from 1/2010–1/2014 identified 328 patients who had breast MRI and available clinical/pathology data. BPE was categorized according to BI-RADS. The association between BPE and breast cancer molecular subtype/prognostic factors was evaluated.

      Results

      No significant association was present between high BPE and the following: HER2+ tumors, basal tumors, tumors with axillary nodal disease, high nuclear grade tumors, high Ki-67 index tumors or larger tumors.

      Conclusion

      Patients with high BPE may be at increased risk for breast cancer but not necessarily for those cancer subtypes with a poor prognosis.

      Keywords

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