Rare pancreatic masses: a pictorial review of radiological concepts

  • Regis Otaviano Franca Bezerra
    Corresponding author at: São Paulo State Cancer Institute of the Medical School of the University of São Paulo, (ICESP), Av. Dr Arnaldo, 251, São Paulo 01246-000, Brazil.
    São Paulo State Cancer Institute of the Medical School of the University of São Paulo, Department of Radiology, Av Dr Arnaldo 251-1SS, São Paulo, SP 01246-000, Brazil

    Sirio Libanes Hospital, Rua Dona Adma Jafet, 115, 01308-050 São Paulo, Brazil
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  • Marcel Cerqueira Machado
    Sirio Libanes Hospital, Rua Dona Adma Jafet, 115, 01308-050 São Paulo, Brazil

    Department of Clinical Emergencies, University of São Paulo, School of Medicine, Av. Dr. Arnaldo, 455, 01246903 São Paulo, Brazil
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  • Micaela Maciel dos Santos Mota
    São Paulo State Cancer Institute of the Medical School of the University of São Paulo, Department of Radiology, Av Dr Arnaldo 251-1SS, São Paulo, SP 01246-000, Brazil
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  • Tamara Abou Ezzedine
    São Paulo State Cancer Institute of the Medical School of the University of São Paulo, Department of Radiology, Av Dr Arnaldo 251-1SS, São Paulo, SP 01246-000, Brazil
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  • Luiz Tenório de Brito Siqueira
    Presidente Prudente Regional Hospital, 19050680 Presidente Prudente, Brazil

    Nossa Senhora das Graças Hospital, 19015140 Presidente Prudente, Brazil
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  • Giovanni Guido Cerri
    São Paulo State Cancer Institute of the Medical School of the University of São Paulo, Department of Radiology, Av Dr Arnaldo 251-1SS, São Paulo, SP 01246-000, Brazil

    Sirio Libanes Hospital, Rua Dona Adma Jafet, 115, 01308-050 São Paulo, Brazil
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      • A wide range of rare solid/predominantly solid lesions, also called non-ductal pancreatic neoplasm, can affect the pancreas
      • These rare pancreatic lesions can be primary or secondary
      • Differential diagnosis and clinical decisions depends on the knowledge of their main radiologic features
      • CT and MRI are useful methods for their evaluation. Endoscopic ultrasound and functional modalities are complimentary tools
      • Surgical resection is often the major treatment of choice, with some exceptions (e.g. pancreatic lipomas)


      Non-ductal pancreatic neoplasm (NPN) represents a heterogeneous group of pancreatic masses, in which diagnosis and management remain challenging due to their overall rarity. Knowledge of their radiologic features is essential for differential diagnosis and to guide clinical decisions for optimal management. The purpose of this paper was to present radiological patterns of these rare pancreatic tumors, solid or predominantly solid, with emphasis in the differential diagnosis and surgical management.


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