Highlights
- •Adult Pancreatoblastoma is a rare neoplasm presenting with nonspecific clinical and imaging features.
- •No significant difference in age, sex, tumor size, and tumor location was found between patients with and without metastases.
Abstract
Purpose
Our purpose was to report a case of adult pancreatoblastoma, and review the literature
in order to assist clinicians in the management of the disease.
Materials and methods
The demographic, clinical, and imaging findings of 41 patients with pathologically
proven pancreatoblastoma from 1986 to 2017 identified in PubMed were reviewed. The
key words used for searching PubMed were: “pancreatoblastoma”, “pancreatic tumor”,
and “adult pancreatoblastoma.” We also reported the details of a case of adult pancreatoblastoma
treated at our institution.
Results
We identified 41 cases of adult pancreatoblastomas, and the mean age at diagnosis
was 41.4 ± 17.4 years. Pancreatoblastomas occurred in the pancreatic head in 48.4%
of patients, and in 39.0% of cases the tumor was >8 cm in diameter at diagnosis. Patient
age and tumor size were similar between males and females (P = 0.59; P = 0.32, respectively). Metastases was present in 17 of the 41 adult patients (41.5%).
No significant difference in age, sex, tumor size, and tumor location was found between
patients with and without metastases (P = 0.57, 0.58, 0.64, 0.39, respectively).
Conclusion
Preoperative diagnosis of adult pancreatoblastoma is difficult because of the heterogeneous,
variable cellular differentiation and atypical clinical and imaging features. A pancreatoblastoma
should be considered when tumors in the pancreas are solid and cystic.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Pancreatoblastoma, a rare childhood tumor: a case report.Turk Patoloji Derg. 2017; 33: 164-167
- Pancreatoblastoma. A clinicopathologic study and review of the literature.Am J Surg Pathol. 1995; 19: 1371-1389
- Revisiting metastatic adult pancreatoblastoma. A case and review of the literature.JOP. 2008; 9: 733-738
- Pancreatoblastoma: imaging findings in 10 patients and review of the literature.Radiology. 2000; 214: 476-482
- Pancreatoduodenectomy for carcinoma of the pancreas in an infant; report of a case.Ann Surg. 1957; 145 ([870-72]): 864-870
- The diagnosis and surgical treatment of pancreatoblastoma in adults: a case series and review of the literature.J Gastrointest Surg. 2013; 17: 2153-2161
- Morphogenesis of pancreatoblastoma, infantile carcinoma of the pancreas: report of two cases.Cancer-Am Cancer Soc. 1977; 39: 247-254
- Pancreatoblastoma in an adult: case report and review of the literature.J Gastrointest Surg. 2006; 10: 829-836
- Pancreatoblastoma: an atypical presentation and a literature review.J Gastrointest Cancer. 2017;
- Pathology and genetics of pancreatic neoplasms with acinar differentiation.Semin Diagn Pathol. 2014; 31: 491-497
- Pancreatoblastoma in an adult.Indian J Pathol Microbiol. 2015; 58: 93-95
- Adult pancreatoblastoma: a case report and review of the literature.Oncol Lett. 2015; 9: 2293-2298
- Pancreatic acinar cell carcinoma: a review on molecular profiling of patient tumors.World J Gastroenterol. 2017; 23: 7945-7951
- Pancreatoblastoma in an adult patient. A case report.JOP. 2009; 10: 192-195
- Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.World J Gastroenterol. 2013; 19: 3358-3363
- Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature.J Am Coll Surg. 2005; 200: 965-972
- Multimodality imaging of neoplastic and nonneoplastic solid lesions of the pancreas.Radiographics. 2011; 31: 993-1015
- The many faces of pancreatic serous cystadenoma: radiologic and pathologic correlation.Diagn Interv Imaging. 2017; 98: 191-202
- Imaging features of solid pseudopapillary tumor of the pancreas on multi-detector row computed tomography.World J Gastroenterol. 2009; 15: 829-835
- Risk and protective factors for the occurrence of sporadic pancreatic endocrine neoplasms.Endocr Relat Cancer. 2017; 24: 405-414
- Cystic islet cell tumors: radiologic findings in three cases.Abdom Imaging. 1994; 19: 225-228
- Mucinous cystic neoplasms of pancreas.Gastroenterol Res. 2014; 7: 44-50
- Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT?.Radiographics. 2005; 25: 1451-68-1468-70
- Cystic pancreatic neoplasms: computed tomography and magnetic resonance imaging findings.Int J Pancreatol. 2000; 28: 223-230
Article info
Publication history
Published online: May 03, 2018
Accepted:
May 1,
2018
Received in revised form:
April 27,
2018
Received:
February 26,
2018
Identification
Copyright
© 2018 Published by Elsevier Inc.
