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Adult pancreatoblastoma: A case report and clinicopathological review of the literature

  • Author Footnotes
    1 This authors contributed equally to this work.
    Menglin Chen
    Footnotes
    1 This authors contributed equally to this work.
    Affiliations
    Medical Imaging Teaching and Research Office, Southern Medical University, Guangzhou 510515, Guangdong, China
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  • Author Footnotes
    1 This authors contributed equally to this work.
    Haijie Zhang
    Footnotes
    1 This authors contributed equally to this work.
    Affiliations
    Medical Imaging Teaching and Research Office, Southern Medical University, Guangzhou 510515, Guangdong, China
    Search for articles by this author
  • Yixin Hu
    Affiliations
    Medical Imaging Teaching and Research Office, Southern Medical University, Guangzhou 510515, Guangdong, China
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  • Kai Liu
    Affiliations
    Medical Imaging Teaching and Research Office, Southern Medical University, Guangzhou 510515, Guangdong, China
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  • Yanjia Deng
    Affiliations
    Medical Imaging Teaching and Research Office, Southern Medical University, Guangzhou 510515, Guangdong, China
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  • Yuanmeng Yu
    Affiliations
    Department of Medical Imaging, Jinling Hospital, Nanjing University Medical School, Nanjing 210002, Jiangsu, China
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  • Yulan Wu
    Affiliations
    Medical Imaging Teaching and Research Office, Southern Medical University, Guangzhou 510515, Guangdong, China
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  • Anqi Qi
    Affiliations
    Medical Imaging Teaching and Research Office, Southern Medical University, Guangzhou 510515, Guangdong, China
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  • Yingjia Li
    Correspondence
    Correspondence to: Y. Li, Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China.
    Affiliations
    Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
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  • Ge Wen
    Correspondence
    Correspondence to: G. Wen, Medical Imaging teaching and research office, Southern Medical University, No.1838 Guangzhoudadao Avenue north, Guangzhou 510515, Guangdong, China.
    Affiliations
    Medical Imaging Teaching and Research Office, Southern Medical University, Guangzhou 510515, Guangdong, China
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  • Author Footnotes
    1 This authors contributed equally to this work.

      Highlights

      • Adult Pancreatoblastoma is a rare neoplasm presenting with nonspecific clinical and imaging features.
      • No significant difference in age, sex, tumor size, and tumor location was found between patients with and without metastases.

      Abstract

      Purpose

      Our purpose was to report a case of adult pancreatoblastoma, and review the literature in order to assist clinicians in the management of the disease.

      Materials and methods

      The demographic, clinical, and imaging findings of 41 patients with pathologically proven pancreatoblastoma from 1986 to 2017 identified in PubMed were reviewed. The key words used for searching PubMed were: “pancreatoblastoma”, “pancreatic tumor”, and “adult pancreatoblastoma.” We also reported the details of a case of adult pancreatoblastoma treated at our institution.

      Results

      We identified 41 cases of adult pancreatoblastomas, and the mean age at diagnosis was 41.4 ± 17.4 years. Pancreatoblastomas occurred in the pancreatic head in 48.4% of patients, and in 39.0% of cases the tumor was >8 cm in diameter at diagnosis. Patient age and tumor size were similar between males and females (P = 0.59; P = 0.32, respectively). Metastases was present in 17 of the 41 adult patients (41.5%). No significant difference in age, sex, tumor size, and tumor location was found between patients with and without metastases (P = 0.57, 0.58, 0.64, 0.39, respectively).

      Conclusion

      Preoperative diagnosis of adult pancreatoblastoma is difficult because of the heterogeneous, variable cellular differentiation and atypical clinical and imaging features. A pancreatoblastoma should be considered when tumors in the pancreas are solid and cystic.

      Keywords

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