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Lipo-prostaglandin E1 improves renal hypoxia evaluated by BOLD-MRI in patients with diabetic kidney disease

      Highlights

      • BOLD-MRI techniques are effective in monitoring and assessing renal hypoxia in diabetic kidney disease.
      • Lipo-PGE1 was shown to improve kidney medullay oxygenation in patients with DKD.
      • The possible renoprotective effects of lipo-PGE1 in acute renal ischemic injury and chronic progression to renal failure in DKD.

      Abstract

      Objective

      To evaluate the effect of lipo-PGE1 on renal hypoxia in patients with DKD by BOLD-MRI.

      Materials and methods

      All patients were divided into DKD group and CKD-without-diabetes group. All patients received intravenous 10 μg lipo-PGE1 once daily for 14 days. BOLD-MRI was performed before and after lipo-PGE1 administration to acquire renal CR2* and MR2* values.

      Results

      Renal MR2* value in DKD group after lipo-PGE1 treatment were significantly decreased compared with the baseline. However, no significant differences in MR2* values were found in the CKD-without-diabetes group.

      Conclusions

      Lipo-PGE1 was shown to improve kidney medullary oxygenation in patients with DKD.

      Keywords

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