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(18F)-FDG-PET/MRI of unicentric retroperitoneal Castleman disease in a pediatric patient

  • Negin Rassouli
    Affiliations
    Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106, USA
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  • Verena C. Obmann
    Correspondence
    Corresponding author at: Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106, USA.
    Affiliations
    Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106, USA

    Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital Bern, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland
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  • Linda M. Sandhaus
    Affiliations
    Department of Pathology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH 44106, USA
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  • Karin A. Herrmann
    Affiliations
    Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106, USA
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      Highlights

      • Castleman disease is a very rare cause of retroperitoneal mass in children.
      • PET/MR offers a combination of morphologic and metabolic imaging findings.
      • Typical imaging: avid enhancement, low-moderate FDG uptake and low ADC values
      • PET/MR helps to narrow down the diagnosis in one single examination.

      Abstract

      Castleman disease (CD) is a rare lymphoproliferative disorder of unknown etiology that may occur anywhere in the lymphatic system. Imaging plays an important role in detecting and staging this disease. Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) combines the metabolic information derived from nuclear medical imaging with the high soft tissue resolution from MRI. We review the features of CD in standard diagnostic imaging, analyze the specific imaging findings of CD in FDG-PET/MRI and discuss a potential benefit of PET/MRI based on the case of a 15-year-old female patient with retroperitoneal CD.

      Keywords

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