Association between epicardial fat volume and fractional flow reserve: An analysis of the determination of fractional flow reserve (DeFACTO) study

Published:February 02, 2018DOI:


      • Epicardial fat volume (EFV) is the adipose tissue within the visceral pericardium.
      • Invasive fractional flow reserve (FFR) is a measure of coronary lesion ischemia.
      • We studied the relationship between EFV and FFR in 173 patients.
      • In patients with suspected coronary artery disease, EFV was not associated with FFR.



      This study examines the relationship between epicardial fat volume (EFV) and lesion-specific ischemia by fractional flow reserve (FFR).


      In a study of 173 patients (63.0 ± 8.3 years) undergoing FFR, EFV was determined using cardiac computed tomography. Relationships between EFV and FFR were assessed using multivariable linear and logistic regression.


      Using multivariable linear and logistic regression, no association between EFV and FFR was observed (β [SE] = −0.001 [0.003], P = 0.6, OR [95% CI]: 1.02 [0.94–1.11], P = 0.64, respectively).


      In patients with suspected or known coronary artery disease undergoing invasive angiography, EFV was not associated with FFR.


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