- •DWI hyperintensity is a significant predictive factor for hypervascularization.
- •Most nodular hypervascular transformations to HCC occurred within 3 years.
- •Careful follow-up is needed for nodules in patients with HCC risk factors.
Materials and methods
Abbreviations:OATP (organic anionic transporting polypeptides), HBP (hepatobiliary phase), DWI (diffusion weighted imaging), HHN (hypovascular HBP hypointense nodule), HCC (hepatocellular carcinoma), T1WI (T1 weighted images)
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- Small hepatocellular carcinomas and associated nodular lesions of the liver: pathology, pathogenesis, and imaging findings.Am J Roentgenol. 1993; 160: 1177-1187
- CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part I. Development, growth, and spread: key pathologic and imaging aspects.Radiology. 2014; 272: 635-654
- Multistep human hepatocarcinogenesis: correlation of imaging with pathology.J Gastroenterol. 2009; 44: 112-118
- Differentiation of small (</=2 cm) hepatocellular carcinomas from small benign nodules in cirrhotic liver on gadoxetic acid-enhanced and diffusion-weighted magnetic resonance images.Abdom Imaging. 2015; 40: 64-75
- Non-hypervascular hypointense nodules >/=1 cm on the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging in cirrhotic livers.Dig Dis. 2014; 32: 678-689
- The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging.Eur Radiol. 2011; 21: 2056-2066
- Relationship between signal intensity on hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging and prognosis of borderline lesions of hepatocellular carcinoma.Eur J Radiol. 2012; 81: 3002-3009
- Added value of gadoxetic acid-enhanced hepatobiliary phase MR imaging in the diagnosis of hepatocellular carcinoma.Radiology. 2010; 255: 459-466
- Small hepatocellular carcinomas: improved sensitivity by combining gadoxetic acid-enhanced and diffusion-weighted MR imaging patterns.Radiology. 2012; 264: 761-770
- Additional value of gadoxetic acid-DTPA-enhanced hepatobiliary phase MR imaging in the diagnosis of early-stage hepatocellular carcinoma: comparison with dynamic triple-phase multidetector CT imaging.J Magn Reson Imaging JMRI. 2011; 34: 69-78
- CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part II. Extracellular agents, hepatobiliary agents, and ancillary imaging features.Radiology. 2014; 273: 30-50
- Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma.J Gastroenterol. 2009; 44: 793-798
- Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR imaging—correlation with molecular transporters and histopathologic features.Radiology. 2010; 256: 817-826
- Update on precursor and early lesions of hepatocellular carcinomas.Arch Pathol Lab Med. 2011; 135: 704-715
- Outcome of hypovascular hepatic nodules revealing no gadoxetic acid uptake in patients with chronic liver disease.J Magn Reson Imaging JMRI. 2011; 34: 88-94
- Diagnostic criteria for hepatocellular carcinoma 3 cm with hepatocyte-specific contrast-enhanced magnetic resonance imaging.J Hepatol. 2016; 64: 1099-1107
- Evolution of hypointense hepatocellular nodules observed only in the hepatobiliary phase of gadoxetate disodium-enhanced MRI.Am J Roentgenol. 2011; 197: 58-63
- Which is the best MRI marker of malignancy for atypical cirrhotic nodules: hypointensity in hepatobiliary phase alone or combined with other features? Classification after Gd-EOB-DTPA administration.J Magn Reson Imaging. 2012; 36: 648-657
- Hypovascular hypointense nodules on hepatobiliary phase gadoxetic acid-enhanced MR images in patients with cirrhosis: potential of DW imaging in predicting progression to hypervascular HCC.Radiology. 2012; 265: 104-114
- Hypovascular hypointense nodules on hepatobiliary phase without T2 hyperintensity on gadoxetic acid-enhanced MR images in patients with chronic liver disease: long-term outcomes and risk factors for hypervascular transformation.Eur Radiol. 2016; 26: 3728-3736
- Hypovascular nodules in patients with chronic liver disease: risk factors for development of hypervascular hepatocellular carcinoma.Radiology. 2013; 266: 480-490
- Comparison of diffusion-weighted imaging and gadoxetic acid-enhanced MR images in the evaluation of hepatocellular carcinoma and hypovascular hepatocellular nodules.Clin Imaging. 2015; 39: 468-475
- Role of diffusion-weighted imaging, apparent diffusion coefficient and correlation with hepatobiliary phase findings in the differentiation of hepatocellular carcinoma from dysplastic nodules in cirrhotic liver.Eur Radiol. 2015; 25: 1087-1096
- Nonhypervascular hypointense nodules at gadoxetic acid-enhanced MR imaging in chronic liver disease: diffusion-weighted imaging for characterization.Radiology. 2015; 276: 137-146
- MR imaging of hepatocellular carcinoma in the cirrhotic liver: challenges and controversies.Radiology. 2008; 247: 311-330
- A biomathematical approach to clinical tumor growth.Cancer. 1961; 14: 1272-1294
- Natural course of hypovascular nodules detected on gadoxetic acid-enhanced MR imaging: presence of fat is a risk factor for hypervascularization.Magn Reson Med Sci MRMS Off J Jpn Soc Magn Reson Med. 2013; 12: 281-287
- High-risk nodules detected in the hepatobiliary phase of Gd-EOB-DTPA-enhanced MR imaging in cirrhosis or chronic hepatitis: incidence and predictive factors for hypervascular transformation, preliminary results.J Magn Reson Imaging JMRI. 2013; 37: 1377-1383
- Imaging features of subcentimeter hypointense nodules on gadoxetic acid-enhanced hepatobiliary phase MR imaging that progress to hypervascular hepatocellular carcinoma in patients with chronic liver disease.Acta Radiol. 2015; 56: 526-535
- Nondysplastic nodules that are hyperintense on T1-weighted gradient-echo MR imaging: frequency in cirrhotic patients undergoing transplantation.Am J Roentgenol. 2003; 180: 1023-1027
- Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma.Lancet. 1990; 336: 1150-1153
- Diffusion-weighted MR imaging for liver lesion characterization: a critical look.Radiology. 2012; 262: 378-380