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The unusual suspects: A review of unusual benign and malignant male breast imaging cases

Published:December 28, 2017DOI:https://doi.org/10.1016/j.clinimag.2017.12.012

      Highlights

      • Men with breast symptoms create unique diagnostic challenges for a radiologist.
      • Accurate clinical history with imaging can aid accurate male breast diagnosis.
      • Ductal pathology is much more common than lobular pathology in men.

      Abstract

      Male breast disease is uncommon. Men presenting with breast symptoms may represent unique diagnostic challenges for the radiologist, particularly if imaging findings are not classic for gynecomastia or carcinoma. In this paper we review 10 unusual male breast cases, 5 benign and 5 malignant, including the radiologic findings, differential diagnosis, pathology and management.

      Keywords

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      References

        • Gunhan-Bilgen I.
        • Bozkaya H.
        • Ustun E.E.
        • Memis A.
        Male breast disease: clinical, mammographic, and ultrasonographic features.
        Eur J Radiol. 2002; 43: 246-255
        • Chantra P.K.
        • So G.J.
        • Wollman J.S.
        • Bassett L.W.
        Mammography of the male breast.
        AJR. 1995; 164: 853-858
        • Giordano S.H.
        A review of the diagnosis and management of male breast cancer.
        Oncologist. 2005; 10: 471-479
        • Nguyen C.
        • Kettler M.D.
        • Swirsky M.E.
        • et al.
        Male breast disease: pictorial review with radiologic-pathologic correlation.
        Radiographics. 2013; 33: 763-779
        • Stavros A.T.
        Evaluation of the male breast.
        in: Breast Ultrasound. Lippincott Williams & Wilkins, Philadelphia, PA2004: 712-714
        • Chen L.
        • Chantra P.K.
        • Larsen L.H.
        • et al.
        Imaging characteristics of malignant lesions of the male breast.
        Radiographics. 2006; 26: 993-1006
        • Erhan Y.
        • Zekioglu O.
        • Erhan Y.
        Invasive lobular carcinoma of the male breast.
        Can J Surg. 2006; 49: 365-366
        • Albayrak Z.K.
        • Onay H.K.
        • Karatag G.Y.
        • Karatag O.
        Invasive lobular carcinoma of the breast: mammographic and sonographic evaluation.
        Diagn Interv Radiol. 2011; 17: 232-238
        • Muttarak M.
        • Lerttumnongtum P.
        • Chaiwun B.
        • et al.
        Spectrum of papillary lesions of the breast: clinical imaging, and pathologic correlation.
        AJR. 2008; 191: 700-707
        • Burga A.M.
        • Fadare O.
        • Lininger R.A.
        • Tavassoli F.A.
        Invasive carcinomas of the male breast: a morphologic study of the distribution of histologic subtypes and metastatic patterns in 778 cases.
        Virchows Arch. 2006; 449: 507-512
        • Yang W.T.
        • Whitman G.J.
        • Yuen E.H.
        • Tse G.M.
        • Stelling C.B.
        Sonographic features of primary breast cancer in men.
        AJR. 2001; 176: 413-416
        • Iuanow E.
        • Kettler M.
        • Slanetz P.J.
        Spectrum of disease in the male breast.
        AJR. 2011; 196: 247-259
        • Lattin G.E.
        • Jessinger R.A.
        • Mattu R.
        • et al.
        From the radiologic pathology archives: diseases of the male breast: radiologic-pathologic correlation.
        Radiographics. 2013; 33: 461-489
        • Liberman L.
        • Tornos C.
        • Huzjan R.
        • Bartella L.
        • Morris E.A.
        • Dershaw D.D.
        Is surgical excision warranted after benign, concordant diagnosis of papilloma at percutaneous breast biopsy?.
        AJR. 2006; 186: 1328-1334
        • Pezzi C.M.
        • Patel-Parekh L.
        • Cole K.
        • et al.
        Characteristics and treatment of metaplastic breast cancer: analysis of 892 cases from the National Cancer Data Base.
        Ann Surg Oncol. 2007; 14: 166-173
        • Beatty J.D.
        • Atwood M.
        • Tickman R.
        • Reiner M.
        Metaplastic breast cancer: clinical significance.
        Am J Surg. 2006; 191: 657-664
        • Volk-Draper L.D.
        • Rajput S.
        • Hall K.L.
        • Wilber A.
        • Ran S.
        Novel model for basaloid triple-negative breast cancer: behavior in vivo and response to therapy.
        Neoplasia. 2012; 14: 926-942
        • Onitilo A.A.
        • Engel J.M.
        • Greenlee R.T.
        • Mukesh B.
        Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival.
        Clin Med Res. 2009; 7: 4-13
        • Gunhan-Bilgen I.
        • Memis A.
        • Üstün E.E.
        • Zekioglu O.
        • Özdemir N.
        Metaplastic carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation.
        AJR. 2002; 178: 1421-1425
        • Gibson G.R.
        • Qian D.
        • JK Ku
        • Lai L.L.
        Metaplastic breast cancer: clinical features and outcomes.
        Am Surg. 2005; 71: 725-730
        • Feder J.M.
        • Shaw de Paredes E.
        • Hogge J.P.
        • Wilken J.J.
        Unusual breast lesions: radiologic-pathologic correlation.
        Radiographics. 1999; 19: S11-S26
        • Surov A.
        • Holzhausen H.J.
        • Wienke A.
        • et al.
        Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features.
        Br J Radiol. 2012; 85: e195-e205
        • Irshad A.
        • Ackerman S.J.
        • Pope T.L.
        • Moses C.K.
        • Rumboldt T.
        • Panzegrau B.
        Rare breast lesions: correlation of imaging and histologic features with WHO classification.
        Radiographics. 2008; 28: 1399-1414
        • Georgiannos S.N.
        • Chin J.
        • Goode A.W.
        • Sheaff M.
        Secondary neoplasms of the breast: a survey of the 20th century.
        Cancer. 2001; 92: 2259-2266
        • Chung S.Y.
        • KK Oh.
        Imaging findings of metastatic disease to the breast.
        Yonsei Med J. 2001; 42: 497-502
        • Mesurolle B.
        • Sygal V.
        • Lalondez L.
        • et al.
        Sonographic and mammographic appearances of breast hemangioma.
        AJR. 2008; 191: W17-W22
        • Lesueur G.C.
        • Brown R.W.
        • Bhathal P.S.
        Incidence of perilobular hemangioma in the female breast.
        Arch Pathol Lab Med. 1983; 107: 308-310
        • Applebaum A.H.
        • Evans G.F.
        • Levy K.R.
        • Amirkhan R.H.
        • Schumpert T.D.
        Mammographic appearance of male breast disease.
        Radiographics. 1999; 19: 559-568
        • Paliotta A.
        • Sapienza P.
        • D'Ermo G.
        • et al.
        Epidermal inclusion cyst of the breast: a literature review.
        Oncol Lett. 2016; 11: 657-660
        • Toorians A.W.
        • Thomassen M.C.
        • Zweegman S.
        • et al.
        Venous thrombosis and changes of hemostatic variables during cross-sex hormone treatment in transsexual people.
        J Clin Endocrinol Metab. 2003; 88: 5723-5729
        • Harris M.
        • Rizvi S.
        • Hindmarsh J.
        • Bryan R.
        Testicular tumour presenting as gynecomastia.
        BMJ. 2006 Apr 8; 332: 837
        • Braunstein G.D.
        Clinical practice: gynecomastia.
        N Engl J Med. 2007; 357: 1229-1237
        • Taboada J.L.
        • Stephens T.W.
        • Krishnamurthy S.
        • Brandt K.R.
        • Whitman G.J.
        The many faces of fat necrosis in the breast.
        AJR. 2009; 192: 815-825
        • Hubeny C.M.
        • Sykes J.B.
        • O'Connell A.
        • Dogra V.S.
        Pilomatrixoma of the adult male breast: a rare tumor with typical ultrasound feature.
        J Clin Imaging Sci. 2011; 1: 1-12
        • Haller J.O.
        • Kassner G.
        • Ostrowitz A.
        • Kottmeier P.K.
        • Pertschuk L.P.
        Pilomatrixoma (Calcifying Epithelioma of Malherbe): radiographic features.
        Radiology. 1977; 123: 151-153