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Characteristics of computed tomography perfusion parameters in non-small-cell-lung-cancer and its relationship to histology, size, stage an treatment response

Published:December 02, 2017DOI:https://doi.org/10.1016/j.clinimag.2017.12.001

      Highlights

      • We analyze CT perfusion parameters in non-small-cell lung cancer.
      • CT perfusion parameters are similar in adenocarcinomas and epidermoid carcinomas.
      • CT perfusión parameters do not predict the response to conventional chemotherapy.
      • Some CT perfusión parameters are higher in the lower stages.

      Abstract

      Objectives

      To analyze computed tomography perfusion (CTP) parameters in NSCLC.

      Materials and methods

      Prospective study, 152 patients with NSCLC. CTP parameters were correlated with histology, stage, size and response to conventional chemotherapy/radiotherapy.

      Results

      Neuroendocrine tumours presented higher BV (p 0.002). Negative correlation of PMB (p 0.003) and positive of MTT (p 0.046) with T stage was found. BF showed negative correlation with size. No differences were found with the RECIST levels of response to chemotherapy/radiotherapy.

      Conclusions

      CTP parameters were highly variable. Neuroendocrine tumours presented higher BV and PMB values. Perfusion parameters do not differ depending on the stage and do not predict response to treatment.

      Abbreviations:

      CTP (computed tomography perfusion), NSCLC (non-small-cell-lung cancer), CTx (chemotherapy), RTx (radiotherapy), BF (blood flow), BV (blood volume), PMB (permeability), MTT (mean transit time), MVD (microvessel density), VEGF (vascular endothelial growth factor), ROI (region of interest), RECIST (Response Evaluation Criteria in Solid Tumours)

      Keywords

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