A retrospective clinicopathological study of lung adenocarcinoma: Total tumor size can predict subtypes and lymph node involvement


      • We validated the predictive impact of the total tumor size on adenocarcinoma subtype and lymph node involvement.
      • Total tumor size of 1.15 cm achieved a sensitivity of 84.44% and specificity 81.4% for differentiating AIS/MIA from IAC.
      • Total tumor size of 1.05cm achieved a sensitivity of 100% and specificity 50% for lymph node involvement.
      • The systematic nodal dissection would be unnecessary if total tumor size is ≤1 cm in diameter in lung adenocarcinoma patient.



      To analyze the predictive ability of total tumor size in lung adenocarcinoma subtype and lymph node involvement.

      Materials and methods

      1018 patients, ≤3 cm tumor, were enrolled. The maximum diameter and other variables of each tumor were measured.


      The optimal cut-off value for total tumor size in differentiating AIS and MIA from IAC was <1.15 cm, in distinguishing lymph node involvement, it was 1.65 cm.


      Total tumor size could be a reliable predictor of lung adenocarcinoma subtype and lymph node involvement irrespective of ground glass, part solid and solid characteristics.


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