Original Article| Volume 45, P111-117, September 2017

Hepatic fat quantification using automated six-point Dixon: Comparison with conventional chemical shift based sequences and computed tomography


      • Automated hepatic fat fraction of 6-p Dixon was accurate correlation with chemical shift imaging.
      • Automated hepatic fat fraction of 6-p Dixon was accurate correlation with CT attenuation value.
      • Imaged fat fraction of 6-p Dixon has the potential for automated hepatic fat quantification.



      To compare automated six-point Dixon (6-p-Dixon) MRI comparing with dual-echo chemical-shift-imaging (CSI) and CT for hepatic fat fraction in phantoms and clinical study.

      Materials and methods

      Phantoms and fifty-nine patients were examined both MRI and CT for quantitative fat measurements.


      In phantom study, linear regression between fat concentration and 6-p-Dixon showed good agreement. In clinical study, linear regression between 6-p-Dixon and dual-echo CSI showed good agreement. CT attenuation value was strongly correlated with 6-p-Dixon (R2 = 0.852; P < 0.001) and dual-echo CSI (R2 = 0.812; P < 0.001).


      Automated 6-p-Dixon and dual-echo CSI were accurate correlation with CT attenuation value of liver parenchyma. 6-p-Dixon has the potential for automated hepatic fat quantification.


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