Highlights
- •Differentiation of remodeled left ventricle myocardium of β-thalassemia major from left ventricle (LV) non-compaction disease using cardiac magnetic resonance (CMR) imaging is still a challenging task.
- •Among the most used CMR criteria, those based on the percentage of non-compacted LV mass are better than the ratio of diastolic non-compacted to compacted myocardium at a segmental level.
Abstract
To differentiate left ventricle non-compaction (LVNC) from hypertrabeculated myocardium
due to LV remodeling in β-thalassemia major (β-TM) patients, cardiac magnetic resonance
(CMR) images of 38 β-TM patients and 10 LVNC patients were compared using 3 diagnostic
criteria: ratio of diastolic segmental non-compacted to compacted myocardium (NC/C
ratio) >2.5, percentage of non-compacted LV mass (NC-LVM%) >20% and >25% of global LV mass. Specificity of NC/C ratio of >2.5 was the lowest (58%) and of NC-LVM% of >25% the highest (93%). A NC-LVM% >20% showed sensitivity 100% and specificity 87%. Disease differentiation depends on
the selected CMR criterion and is better with NC-LVM%.
Keywords
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Article info
Publication history
Published online: May 17, 2017
Accepted:
May 9,
2017
Received in revised form:
April 19,
2017
Received:
January 22,
2017
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
