Highlights
- •Loss of normal high attenuation of enlarged thyroid glands on non-enhanced CT can be a diagnostic clue of Grave’s disease.
- •Enlargement of the right atrium or ventricle on CT may suggest presence of pulmonary hypertension.
- •Chest CT has the potential to diagnose Grave’s disease with pulmonary hypertension in the absence of clinical information.
Abstract
Objective
To evaluate the diagnostic accuracy of chest CT findings to diagnose Grave's disease
in pulmonary hypertension.
Methods
We retrospectively evaluated chest CT and the medical records of 13 patients with
Grave's disease with (n = 6) or without pulmonary hypertension (n = 7) and in 17 control patients.
Results
Presence of iso-attenuation of diffusely enlarged thyroid glands compared with adjacent
neck muscle on non-enhanced CT as a diagnostic clue of Grave's disease, and assessment
of pulmonary hypertension on CT has high diagnostic accuracy.
Conclusion
Chest CT has the potential to diagnose Grave's disease with pulmonary hypertension
in the absence of other information.
Keywords
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References
- Imaging thyroid disease: updates, imaging approach, and management pearls.Radiol Clin North Am. 2015; 53: 145-161
- Diagnosis and management of thyrotoxicosis.BMJ. 2014; 349: g5128
- Thyroid hormone and the cardiovascular system.N Engl J Med. 2001; 344: 501-509
- Thyroid disease and the heart.Circulation. 2007; 116: 1725-1735
- Pulmonary hypertension and predominant right heart failure in thyrotoxicosis.Resuscitation. 2006; 69: 339-341
- Correlation of CT values, iodine concentration, and histological changes in the thyroid.J Comput Assist Tomogr. 2000; 24: 322-326
- Clinical studies on thyroid CT number in Graves' disease and destructive thyrotoxicosis.Endocr J. 1994; 41: 25-30
- Diagnostic value of CT density in patients with diffusely increased FDG uptake in the thyroid gland on PET/CT images.AJR Am J Roentgenol. 2010; 195: 223-228
- Thymic hyperplasia in a patient with Grave's disease.Int Arch Med. 2012; 5: 5-6
- Thymic hyperplasia and Graves disease: management of anterior mediastinal masses in patients with Graves disease.Endocr Pract. 2009; 15: 534-539
- Thymic hyperplasia in patients with Graves' disease. Identification of thyrotropin receptors in human thymus.J Clin Invest. 1996; 98: 2228-2234
- Graves' disease and massive thymic hyperplasia.Thyroid. 2010; 20: 227-229
- Graves' disease and thymic hyperplasia: the relationship of thymic volume to thyroid function.Thyroid. 2010; 20: 1015-1028
- Computed tomography of the normal thymus.Radiology. 1982; 142: 121-125
- The thymus: reexamination of age-related changes in size and shape.AJR Am J Roentgenol. 1985; 145: 249-254
- A case of thymic enlargement in hyperthyroidism in a young woman.Thyroid. 2004; 14: 307-310
- Cardiovascular manifestations of hyperthyroidism before and after antithyroid therapy: a matched case-control study.J Am Coll Cardiol. 2007; 49: 71-81
- Pulmonary hypertension is frequent in hyperthyroidism and normalizes after therapy.Eur J Intern Med. 2006; 17: 267-271
- Autoimmunity and pulmonary hypertension in patients with Graves' disease.Heart Vessels. 2015; 30: 642-646
- Multidetector computed tomography imaging for the diagnosis of hyperthyroid cardiomyopathy.Iran J Radiol. 2017; (in press)
- Right ventricular enlargement on chest computed tomography: a predictor of early death in acute pulmonary embolism.Circulation. 2004; 110: 3276-3280
Article info
Publication history
Published online: March 23, 2017
Accepted:
March 22,
2017
Received in revised form:
March 8,
2017
Received:
October 9,
2016
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.