Highlights
- •MRE helps to identify subgroups of patient candidates to discontinuation of anti-TNF.
- •Silent activity detected by MRE increases more than twofold the risk of relapse.
- •MRE scores are more useful than single MR parameters to predict the relapse.
Abstract
Purpose
This study was performed to assess the ability of magnetic resonance enterography
to predict the evolution of patients in whom anti-tumor necrosis factor-α therapy
was suspended.
Methods
A prospective study of patients with ileal Crohn's disease was performed.
Results
Twenty-nine patients were included. Patients who later relapsed showed higher magnetic
resonance scores than those who did not relapse (4.2 vs. 2.5, respectively; p < 0.02). The area under the receiving-operating characteristics curve was 0.755 when
discriminating patients who relapsed.
Conclusions
Magnetic resonance enterography should be taken into account when deciding the withdrawal
of anti-tumor necrosis factor-α in patients with Crohn's disease.
Keywords
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Article info
Publication history
Published online: March 15, 2017
Accepted:
March 7,
2017
Received in revised form:
February 17,
2017
Received:
September 24,
2016
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
