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Use of hepatobiliary phase images in Gd-EOB-DTPA-enhanced MRI of breast cancer hepatic metastasis to predict response to chemotherapy

      Highlights

      • Metastatic lesions with a target appearance on HBP in Gd-EOB-DTPA MRI showed a poor response to chemotherapy.
      • Metastatic lesions with a high SI ratio on HBP in Gd-EOB-DTPA MRI showed a poor response to chemotherapy.
      • HBP analysis may be useful to predict the response to chemotherapy and survival.

      Abstract

      Objectives

      To determine the prognostic value of Gd-EOB-DTPA MRI findings of liver metastasis from breast cancer.

      Methods

      29 metastatic lesions from 12 breast cancer patients who received chemotherapy were retrospectively reviewed. We evaluated hepatobiliary phase of the lesions and classified them as a “target” or “non-target” appearance. The relationship of appearance or SI ratio with tumor response was analyzed.

      Results

      A non-target appearance was more frequent in disease control group than in non-control group [14/18 (77.8%) vs. 4/18 (22.2%)], and it was associated with a better response [p = 0.048].

      Conclusion

      HBP analysis may be useful to predict the response to chemotherapy and survival.

      Keywords

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