Highlights
- •Pheochromocytomas tend to have different CT imaging features mimicking other tumors according to the size of the tumors.
- •Clinical features and RI study are not different between small and large pheochromocytomas.
- •Although small pheochromocytomas mimicked adrenal adenoma based on CT features that are different from typical pheochromocytomas, small pheochromocytomas shared similar clinical features and RI study results with typical pheochromocytomas.
Abstract
Objective
To evaluate differences in clinical and radiologic features of small and large pheochromocytomas.
Materials and methods
This study included 39 patients with adrenal pheochromocytomas. Several clinical and
radiologic features were statistically analyzed and compared between small and large
pheochromocytomas.
Results
No significant differences were found in clinical features between them. Small pheochromocytomas
had more relatively homogeneous attenuation although large pheochromocytomas had more
cystic or necrotic changes.
Conclusions
Pheochromocytomas tend to have different CT imaging features mimicking other tumors
according to the size of the tumors. However, clinical features, CT imaging characteristics,
and radioisotope activity are not different between small and large pheochromocytomas.
Keywords
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References
- Sensitivity of diagnostic and localization tests for pheochromocytoma in clinical practice.Arch. Intern. Med. 2000; 160: 2521-2524
- From the radiologic pathology archives: adrenal tumors and tumor-like conditions in the adult: radiologic-pathologic correlation.Radiographics. 2014; 34: 805-829
- Pheochromocytoma: an imaging chameleon.Radiographics. 2004; 24: S87-S99
- Adrenal masses differentiated by MR.Radiology. 1986; 158: 81-84
- Incidental adrenal lesions: principles, techniques, and algorithms for imaging characterization 1.Radiology. 2008; (756–75)
- Adrenal mass imaging with multidetector CT: pathologic conditions, pearls, and pitfalls.Radiographics. 2009; 29: 1333-1351
- Adrenal incidentaloma: an overview of clinical and epidemiological data from the National Italian Study Group.Horm. Res. 1997; 47: 279-283
- CT time-attenuation washout curves of adrenal adenomas and nonadenomas.Am. J. Roentgenol. 1998; 170: 747-752
- Delayed enhanced CT of lipid-poor adrenal adenomas.Am. J. Roentgenol. 2000; 175: 1411-1415
- Adrenal masses: characterization with combined unenhanced and delayed enhanced CT.Radiology. 2002; 222: 629-633
- Plasma and 24 h-urinary catecholamine concentrations in normal and patient populations.Ann. Clin. Biochem. 1993; 30: 38-44
- Management approaches to adrenal incidentalomas. A view from Rochester, Minnesota.Endocrinol. Metab. Clin. N. Am. 2000; 29: 159-185
- Pheochromocytoma: study of 50 cases.J. Urol. 1997; 157: 1208-1212
- Comparison of CT findings in symptomatic and incidentally discovered pheochromocytomas.Am. J. Roentgenol. 2005; 185: 684-688
- Laparoscopic adrenalectomy for pheochromocytoma.World J. Surg. 2002; 26: 1048-1051
- Circumstances of discovery of phaeochromocytoma: a retrospective study of 41 consecutive patients.Eur. J. Endocrinol. 2004; 150: 681-686
- Clinical experience with incidentally discovered pheochromocytoma.J. Urol. 1997; 157: 1566-1568
- Low-density pheochromocytoma on CT: a mimicker of adrenal adenoma.AJR Am. J. Roentgenol. 2003; 181: 1663-1668
- Pheochromocytoma: study of 50 cases.J. Urol. 1997; 157: 1208-1212
- A comparison of biochemical tests for pheochromocytoma: measurement of fractionated plasma metanephrines compared with the combination of 24-hour urinary metanephrines and catecholamines.J. Clin. Endocrinol. Metab. 2003; 88: 553-558
- Pheochromocytoma: advances in genetics, diagnosis, localization, and treatment.Hematol. Oncol. Clin. North Am. 2007; 21: 509-525
- Adrenal phaeochromocytoma: correlation of MRI appearances with histology and function.Eur. Radiol. 2008; 18: 2885-2892
- Re-evaluation of pheochromocytomas on delayed contrast-enhanced CT: washout enhancement and other imaging features.Eur. Radiol. 2007; 17: 2804-2809
- Can established CT attenuation and washout criteria for adrenal adenoma accurately exclude pheochromocytoma?.Am. J. Roentgenol. 2013; 201: 122-127
- Iodine-131 metaiodobenzylguanidine for the locating of suspected pheochromocytoma: experience in 400 cases.J. Nucl. Med. 1985; 26: 576-5
- 123I-metaiodobenzylguanidine (MIBG) scintigraphy for the detection of adrenal and extra-adrenal phaeochromocytomas: CT and MRI correlation.Clin. Endocrinol. 2008; 69: 181-188
- Pheochromocytoma.J. Clin. Hypertens. (Greenwich). 2002; 4: 62-72
Article info
Publication history
Published online: March 09, 2017
Accepted:
March 7,
2017
Received in revised form:
January 24,
2017
Received:
July 22,
2016
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
