Tumefactive demyelination associated with developmental venous anomaly: Report of two cases

Published:February 28, 2017DOI:


      • We present two cases of tumefactive demyelination (TD) occurring in proximity to a DVA.
      • There has only been one previously reported case of this finding in the literature.
      • Venous derangement has been hypothesized to play a role in demyelination.
      • The DVA or its effects on the adjacent tissue may have potentiated the development of TD.
      • Recognizing imaging features of TD may avoid invasive procedures on this “do not touch” lesion.


      We present two cases of tumefactive demyelination (TD) occurring in close association with a developmental venous anomaly (DVA). Our purpose is to describe the association between demyelinating lesions and venous anomalies, as only one case of TD associated with a DVA has been published in the literature. Appropriate recognition of this “do not touch” lesion may avoid invasive and potentially harmful procedures such as biopsy or resection.


      TD (tumefactive demyelination), DVA (developmental venous anomaly), AML (acute myelogenous leukemia)


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