Highlights
- •We present two cases of tumefactive demyelination (TD) occurring in proximity to a DVA.
- •There has only been one previously reported case of this finding in the literature.
- •Venous derangement has been hypothesized to play a role in demyelination.
- •The DVA or its effects on the adjacent tissue may have potentiated the development of TD.
- •Recognizing imaging features of TD may avoid invasive procedures on this “do not touch” lesion.
Abstract
We present two cases of tumefactive demyelination (TD) occurring in close association
with a developmental venous anomaly (DVA). Our purpose is to describe the association
between demyelinating lesions and venous anomalies, as only one case of TD associated
with a DVA has been published in the literature. Appropriate recognition of this “do
not touch” lesion may avoid invasive and potentially harmful procedures such as biopsy
or resection.
Abbreviations:
TD (tumefactive demyelination), DVA (developmental venous anomaly), AML (acute myelogenous leukemia)Keywords
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References
- The role of venous abnormalities in neurological disease.Rev Recent Clin Trials. 2012; 7: 100-116
- MR venography of multiple sclerosis.AJNR Am J Neuroradiol. 2000; 21: 1039-1042
- Characteristic neuroimaging in patients with tumefactive demyelinating lesions exceeding 30 mm.J Neuroimaging. 2011; 21: e69-e77
- Evidence of acute demyelination around a developmental venous anomaly: magnetic resonance imaging findings.Invest Radiol. 1997; 32: 575-577
- Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making.NeuroRx. 2005; 2: 197-214
- Clinical proton MR spectroscopy in central nervous system disorders.Radiology. 2014; 270: 658-679
- Venous endothelial injury in central nervous system diseases.BMC Med. 2013; 11: 219
- Cerebral developmental venous anomalies.Childs Nerv Syst. 2010; 26: 1395-1406
- Developmental venous anomaly causing trigeminal neuralgia.Arq Neuropsiquiatr. 2010; 68: 822-825
- Parenchymal hypointense foci associated with developmental venous anomalies: evaluation by phase-sensitive MR imaging at 3T.AJNR Am J Neuroradiol. 2013; 34: 1940-1944
- Parenchymal abnormalities associated with developmental venous anomalies.Neuroradiology. 2007; 49: 987-995
- Brain parenchymal signal abnormalities associated with developmental venous anomalies: detailed MR imaging assessment.AJNR Am J Neuroradiol. 2008; 29: 1317-1323
- Unilateral calcification of the caudate and putamen: association with underlying developmental venous anomaly.AJNR Am J Neuroradiol. 2010; 31: 1848-1852
- Association of developmental venous anomalies with perfusion abnormalities on arterial spin labeling and bolus perfusion-weighted imaging.J Neuroimaging. 2015; 25: 243-250
- Venous-predominant parenchymal arteriovenous malformation: a rare subtype with a venous drainage pattern mimicking developmental venous anomaly.J Neurosurg. 2008; 108: 1142-1147
- Characterization of tumefactive demyelinating lesions using MR imaging and in-vivo proton MR spectroscopy.Mult Scler. 2009; 15: 193-203
Article info
Publication history
Published online: February 28, 2017
Accepted:
February 25,
2017
Received:
January 20,
2017
Footnotes
☆This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
☆Paper previously presented in part at the Annual Meeting of the American Society of Neuroradiology, May 2015; Chicago, IL.
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
