Original Article| Volume 43, P19-23, May 2017

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Comparison of low-dose coronary artery calcium scoring using low tube current technique and hybrid iterative reconstruction vs. filtered back projection

Published:February 01, 2017DOI:


      • Hybrid Iterative reconstruction with low dose CACS CT enables stable coronary calcium quantification as full dose FBP.
      • Using HIR low dose CACS, no patient changed risk group from positive to zero or vice versa.
      • Automatic exposure control allowed standardization of image quality and radiation dose exposure.



      We sought to validate whether low dose CACS CT with hybrid IR (HIR) could replace standard dose filtered back projection (FBP).


      We enrolled 100 patients to undergo low dose CACS CT with HIR, in addition to routine full dose FBP.


      No significant difference between full and low dose CT in Agatston score 138.2 ± 360.6 vs. 137.3 ± 356.4 (p = 0.272) or calcium mass score 19 ± 48.3 vs. 18.7 ± 49 (p = 0.8), respectively. Bland–Altman analysis showed no systematic bias. Calcium volume difference was statistically significant 57.2 ± 134 vs. 55.1 ± 130.2 (p = 0.001).


      Low dose CT for calcium scoring with HIR enables stable CACS Agatston score and calcium mass quantification as compared to full dose FBP.

      Graphical abstract


      CACS (coronary artery calcium score), HIR (hybrid iterative reconstruction), FBP (filtered back projection), FD (full dose), LD (low dose), BMI (body mass index), DLP (dose-length product)


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