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Quantitative analysis of gadoxetic acid-enhanced magnetic resonance imaging predicts histological grade of hepatocellular carcinoma

      Highlights

      • The correlations among signal absolute enhancement, contrast enhancement ratio (CER) and histological grade were analyzed.
      • We use CER of tumor-to-liver calculated by the equation SIth − SItu/SIlh − SIlu to evaluate Gd-EOB-DTPA-enhanced MRI.
      • We use the value of contrast enhancement ratio of tumor-to-liver to predict histological grades of small HCCs.

      Abstract

      Objective

      To confirm the histological grade of hepatocellular carcinoma (HCC) by gadoxetic acid-enhanced MRI.

      Methods

      Ninety-five HCC patients underwent gadoxetic acid-enhanced MRI before surgical intervention. The correlations among the signal absolute enhancement, contrast enhancement ratio (CER) and tumor histological grade were analyzed.

      Results

      The correlation between CER of tumor-to-liver and the grades of tumor differentiation is the most significant negative. The k-value for the CER of tumor-to-liver and histopathologic analysis is 0.62, which gives evidence of good agreement.

      Conclusion

      The quantitative analysis of gadoxetic acid-enhanced MRI can predict the histological grades of small HCCs.

      Keywords

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