Abstract
Purpose
To compare MRI features of pathologically-proven hepatocellular carcinoma (HCC) between
patients with hepatitis B (HBV) and hepatitis C (HCV) infection.
Methods
Two radiologists assessed 51 confirmed HCCs on MRI in HBV (n=18) or HCV (n=33) patients; a third, more experienced, radiologist resolved discrepancies.
Results
Arterial hyperenhancement occurred more frequently in HCV (90.9% vs. 66.7%; P=.032), DWI/T2WI hyperintensity more frequently in HBV [(DWI: 78.6% vs. 45.8%, T2WI:
77.8% vs. 48.5%; P=.073–0.088)]. Tumors were larger in HBV (P≤.016). Washout, pseudocapsule, homogeneity, circumscribed margins, lipid, iron, and
visually low ADC were not different.
Conclusion
Larger studies are required to confirm these preliminary findings.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Hepatitis B and C virus-related carcinogenesis.Clin Microbiol Infect. 2009; 15: 964-970
- Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis.J Viral Hepat. 2004; 11: 383-393
- Hepatocellular carcinoma: clinical and radiological findings in patients with chronic B viral hepatitis and chronic C viral hepatitis.Abdom Imaging. 2012; 37: 591-594
- A comparison of the surgical results in patients with hepatitis B versus hepatitis C—related hepatocellular carcinoma.Hepatology. 1995; 22: 20-24
- Comparison of surgical outcomes for small hepatocellular carcinoma in patients with hepatitis B versus hepatitis C: a Chinese experience.J Gastroenterol Hepatol. 2007; 22: 1936-1941
- Hepatitis B- and C-related hepatocellular carcinomas yield different clinical features and prognosis.Eur J Cancer. 2006; 42: 2524-2529
- Comparison of surgical outcomes for hepatocellular carcinoma in patients with hepatitis B versus hepatitis C: a western experience.Ann Surg Oncol. 2000; 7: 764-770
- Chronic viral hepatitis and hepatocellular carcinoma.World J Surg. 2007; 31: 1243-1248
- A comparison of the surgical outcomes among patients with HBV-positive, HCV-positive, and Non-B Non-C hepatocellular carcinoma: a nationwide study of 11,950 patients.Ann Surg. 2015; 261: 513-520
- Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma.Am J Gastroenterol. 2006; 101: 91-98
- Comparison of the clinical characteristics among hepatocellular carcinoma of hepatitis B, hepatitis C and non-B non-C patients.Hepatogastroenterology. 2003; 50: 2022-2027
- A comparison of patients with hepatitis B– or hepatitis C–based advanced-stage hepatocellular carcinoma.Semin Oncol. 2015; 42: 309-315
- Diffusion-weighted imaging of surgically resected hepatocellular carcinoma: imaging characteristics and relationship among signal intensity, apparent diffusion coefficient, and histopathologic grade.AJR Am J Roentgenol. 2009; 193: 438-444
- High-b-value diffusion-weighted MR imaging of hepatocellular lesions: estimation of grade of malignancy of hepatocellular carcinoma.J Magn Reson Imaging. 2009; 30: 1005-1011
- MRI-based staging of hepatic fibrosis: comparison of intravoxel incoherent motion diffusion-weighted imaging with magnetic resonance elastography.J Magn Reson Imaging. 2015; 42: 204-210
- Assessing liver fibrosis: comparison of arterial enhancement fraction and diffusion-weighted imaging.J Magn Reson Imaging. 2014; 40: 1137-1146
- Diffusion-weighted MRI of hepatocellular carcinoma in cirrhosis.Clin Radiol. 2014; 69: 1-10
- LI-RADS: a case-based review of the new categorization of liver findings in patients with end-stage liver disease.Radiographics. 2012; 32: 1977-1995
- Higher sensitivity and specificity for diffusion-weighted imaging of malignant lung lesions without apparent diffusion coefficient uantification.Radiology. 2009; 252: 247-254
Article info
Publication history
Published online: January 27, 2016
Accepted:
January 26,
2016
Received in revised form:
December 21,
2015
Received:
October 8,
2015
Footnotes
Support: None.
Disclosures: None.
Conflicts of interest: None.
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.