Abstract
Purpose
To investigate the value of diffusion-weighted imaging (DWI) for differentiating gallbladder
adenocarcinoma from adenoma, and predicting histologic grades of gallbladder adenocarcinoma.
Materials and methods
Fourty-three gallbladder adenocarcinomas and 8 adenomas were included. We compared
apparent diffusion coefficient (ADC) values between adenocarcinoma and adenoma, and
ADC values of gallbladder adenocarcinoma among the histologic grade.
Results
Gallbladder adenocarcinoma (1.041×10−3 mm2/s) showed significantly lower ADC values than adenoma (2.039×10−3 mm2/s) (P<.001). Well-differentiated adenocarcinoma (1.290×10−3 mm2/s) showed significantly higher ADC values than higher-grades (1.104×10−3 and 0.915×10−3 mm2/s in moderately- and poorly-differentiated, respectively) (P<.001).
Conclusion
DWI can help to differentiate gallbladder adenocarcinoma from adenoma, and well-differentiated
from higher-grade adenocarcinoma.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Gallbladder cancer.Semin Surg Oncol. 2000; 19: 145-155
- Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates.Cancer. 1992; 70: 1493-1497
- Prognostic factors in patients with gallbladder cancer after surgical resection: analysis of 279 operated patients.J Clin Gastroenterol. 2013; 47: 443-448
- Tumors of the gallbladder and cystic duct.in: Lack E.E. Albores-Saavedra J. Pathology of the pancreas, gallbladder, extrahepatic biliary tract, and ampullary region. Oxford University Press Inc, New York2003: 465-510
- MDCT in the staging of gallbladder carcinoma.Am J Roentgenol. 2006; 186: 758-762
- Computed tomography for assessing resectability of gallbladder carcinoma: a systematic review and meta-analysis.Clin Imaging. 2013; 37: 327-333
- Preoperative evaluation of gallbladder carcinoma: efficacy of combined use of MR imaging, MR cholangiography, and contrast-enhanced dual-phase three-dimensional MR angiography.J Magn Reson Imaging. 2002; 16: 676-684
- Diagnosis and staging of gallbladder carcinoma. Evaluation with dynamic MR imaging.Clin Imaging. 2002; 26: 177-182
- 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer.J Am Coll Surg. 2008; 206: 57-65
- Diffusion-weighted MRI in the body: applications and challenges in oncology.Am J Roentgenol. 2007; 188: 1622-1635
- Diffusion-weighted imaging of biliopancreatic disorders: correlation with conventional magnetic resonance imaging.World J Gastroenterol. 2012; 18: 4102-4117
- Diffusion-weighted imaging of surgically resected hepatocellular carcinoma: imaging characteristics and relationship among signal intensity, apparent diffusion coefficient, and histopathologic grade.Am J Roentgenol. 2009; 193: 438-444
- Urinary bladder cancer: diffusion-weighted MR imaging–accuracy for diagnosing T stage and estimating histologic grade.Radiology. 2009; 251: 112-121
- Diffusion-weighted MRI in renal cell carcinoma: a surrogate marker for predicting nuclear grade and histological subtype.Acta Radiol. 2012; 53: 349-358
- Diffusion-weighted MRI in rectal cancer: apparent diffusion coefficient as a potential noninvasive marker of tumor aggressiveness.J Magn Reson Imaging. 2012; 35: 1365-1371
- Diffusion-weighted MRI for differentiation of benign from malignant lesions in the gallbladder.Clin Radiol. 2013; 69: e78-e85
- High b-value diffusion-weighted MRI for detecting gallbladder carcinoma: preliminary study and results.Eur Radiol. 2009; 19: 1794-1798
- High b-value diffusion-weighted MRI in differentiation between benign and malignant polypoid gallbladder lesions.Acta Radiol. 2011; 52: 236-240
- High b-value diffusion-weighted magnetic resonance imaging for gallbladder lesions: differentiation between benignity and malignancy.J Gastroenterol. 2012; 47: 1352-1360
- Role of diffusion-weighted magnetic resonance imaging in the diagnosis of gallbladder cancer.J Magn Reson Imaging. 2013; 38: 127-137
- Gallbladder carcinoma: radiologic-pathologic correlation.Radiographics. 2001; 21: 295-314
- Lung carcinoma: diffusion-weighted mr imaging–preliminary evaluation with apparent diffusion coefficient.Radiology. 2007; 243: 570-577
- Gallbladder cancer: adenoma-carcinoma or dysplasia-carcinoma sequence?.Gastroenterol Hepatol. 2008; 4: 735-737
- Polypoid lesions of the gallbladder: disease spectrum with pathologic correlation.Radiographics. 2015; 35: 387-399
- Clinicopathologic features of polypoid lesions of the gallbladder and risk factors of gallbladder cancer.J Korean Med Sci. 2009; 24: 481-487
- Polypoid lesions of the gallbladder: report of 100 cases with special reference to operative indications.Surgery. 2000; 127: 622-627
- Dynamic MRI of the gallbladder lesions: differentiation of benign from malignant.J Magn Reson Imaging. 1997; 7: 696-701
- Differentiation of nonneoplastic and neoplastic gallbladder polyps 1 cm or bigger with multi-detector row computed tomography.J Comput Assist Tomogr. 2010; 34: 135-139
- CT differentiation of 1-2-cm gallbladder polyps: benign vs malignant.Abdom Imaging. 2014; 39: 334-341
- Carcinoma of the gallbladder and extrahepatic bile ducts.in: Hamilton S.R. Aaltonen L.A. World health organization classification of tumours: pathology and genetics of tumours of the digestive system. IARC Press, Lyon, France2000: 206-213
- Glioma grading: sensitivity, specificity, positive and negative predictive values of diffusion and perfusion imaging.J Neurooncol. 2009; 94: 87-96
- Tumour ADC measurements in rectal cancer: effect of ROI methods on ADC values and interobserver variability.Eur Radiol. 2011; 21: 2567-2574
Article info
Publication history
Published online: January 22, 2016
Accepted:
January 15,
2016
Received in revised form:
December 8,
2015
Received:
September 21,
2015
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
