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Diffusion-weighted magnetic resonance imaging of gallbladder adenocarcinoma: analysis with emphasis on histologic grade

  • Nam Kyung Lee
    Affiliations
    Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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  • Suk Kim
    Correspondence
    Corresponding author. Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, #305, GuDeok-Ro, Seo-Gu, Busan, 602-739, Korea. Tel.: +1 82 51/240 7354; fax: +82 51/244 7534.
    Affiliations
    Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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  • Jin Il Moon
    Affiliations
    Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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  • Nari Shin
    Affiliations
    Department of Pathology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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  • Dong Uk Kim
    Affiliations
    Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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  • Hyung Il Seo
    Affiliations
    Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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  • Hyun Sung Kim
    Affiliations
    Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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  • Ga Jin Han
    Affiliations
    Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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  • Jin You Kim
    Affiliations
    Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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  • Ji Won Lee
    Affiliations
    Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, 602-739, Republic of Korea
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      Abstract

      Purpose

      To investigate the value of diffusion-weighted imaging (DWI) for differentiating gallbladder adenocarcinoma from adenoma, and predicting histologic grades of gallbladder adenocarcinoma.

      Materials and methods

      Fourty-three gallbladder adenocarcinomas and 8 adenomas were included. We compared apparent diffusion coefficient (ADC) values between adenocarcinoma and adenoma, and ADC values of gallbladder adenocarcinoma among the histologic grade.

      Results

      Gallbladder adenocarcinoma (1.041×10−3 mm2/s) showed significantly lower ADC values than adenoma (2.039×10−3 mm2/s) (P<.001). Well-differentiated adenocarcinoma (1.290×10−3 mm2/s) showed significantly higher ADC values than higher-grades (1.104×10−3 and 0.915×10−3 mm2/s in moderately- and poorly-differentiated, respectively) (P<.001).

      Conclusion

      DWI can help to differentiate gallbladder adenocarcinoma from adenoma, and well-differentiated from higher-grade adenocarcinoma.

      Keywords

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