Abstract
Aim
To evaluate the value of magnetic resonance imaging-detected extramural vascular invasion
(MR-EMVI) in predicting regional lymph node metastasis (RLNM) in patients with rectal
cancer.
Methods
A total of 183 patients were included. A set of clinical and imaging factors including
MR-EMVI were evaluated using univariate and multivariate analyses to determine the
risk factors for RLNM.
Results
Among the clinical and imaging factors evaluated, MR-EMVI, pathologic EMVI, nodal
size, and diffusion-weighted imaging-detected positive nodes were independent predictors
of RLNM.
Conclusions
MR-EMVI may be an independent predictor of RLNM in patients with rectal cancer.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Regional lymph node metastasis and locoregional recurrence of rectal carcinoma in the era of TME [corrected] surgery. Implications for treatment decisions.Int J Color Dis. 2010; 25: 359-368
- Patterns of lymph node metastasis are different in colon and rectal carcinomas.World J Gastroenterol. 2010; 16: 5375-5379
- Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: is it regional or distant disease?.Ann Surg. 2012; 255: 1129-1134
- Rectal cancer: local recurrence after surgery without radiotherapy.Dis Colon Rectum. 2001; 44: 374-379
- Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial.Lancet. 2009; 373: 811-820
- Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial.Lancet Oncol. 2011; 12: 575-582
- Phase II, randomized study of concomitant chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in magnetic resonance imaging-defined, locally advanced rectal cancer: Grupo cancer de recto 3 study.J Clin Oncol. 2010; 28: 859-865
- Adverse effects of preoperative radiation therapy for rectal cancer: long-term follow-up of the Swedish Rectal Cancer Trial.J Clin Oncol. 2005; 23: 8697-8705
- Impact of short-course preoperative radiotherapy for rectal cancer on patients' quality of life: data from the Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 randomized clinical trial.J Clin Oncol. 2010; 28: 4233-4239
- Preoperative evaluation of colorectal cancer using CT colonography, MRI, and PET/CT.World J Gastroenterol. 2014; 20: 16964-16975
- Diagnostic accuracy of MRI for assessment of T category, lymph node metastases, and circumferential resection margin involvement in patients with rectal cancer: a systematic review and meta-analysis.Ann Surg Oncol. 2012; 19: 2212-2223
- Prediction of pathologic staging with magnetic resonance imaging after preoperative chemoradiotherapy in rectal cancer: pooled analysis of KROG 10–01 and 11–02.Radiother Oncol. 2014; 113: 18-23
- Diffusion-weighted MR imaging in primary rectal cancer staging demonstrates but does not characterise lymph nodes.Eur Radiol. 2013; 23: 3354-3360
- Size and distribution of lymph nodes in rectal cancer resection specimens.Dis Colon Rectum. 2015; 58: 406-414
- Evaluation of gadolinium-enhanced T1-weighted magnetic resonance imaging in the preoperative assessment of local staging in rectal cancer.Colorectal Dis. 2010; 12: 1139-1148
- Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer-a per lesion validation study.Eur Radiol. 2011; 21: 265-273
- Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer.Br J Surg. 2008; 95: 229-236
- The Prognostic Significance of Postchemoradiotherapy High-resolution MRI and Histopathology Detected Extramural Venous Invasion in Rectal Cancer.Ann Surg. 2015; 261: 473-479
- MRI for detection of extramural vascular invasion in rectal cancer.AJR Am J Roentgenol. 2008; 191: 1517-1522
- Risk factors for lymph node metastasis in pT1 and pT2 rectal cancer: a single-institute experience in 943 patients and literature review.Ann Surg Oncol. 2012; 19: 2477-2484
- Risk factors of lateral pelvic lymph node metastasis in advanced rectal cancer.Int J Color Dis. 2009; 24: 1085-1090
- The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.Ann Surg Oncol. 2010; 17: 1471-1474
- Local recurrence in rectal cancer can be predicted by histopathological factors.Eur J Surg Oncol. 2009; 35: 1071-1077
- A method of comparing the areas under receiver operating characteristic curves derived from the same cases.Radiology. 1983; 148: 839-843
- Clinical impact of lymph node status in rectal cancer.Surg Oncol. 2011; 20: e227-e233
- Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison.Radiology. 2003; 227: 371-377
- Depth of tumor invasion independently predicts lymph node metastasis in T2 rectal cancer.J Gastrointest Surg. 2011; 15: 130-136
- The prognostic significance of MRI-detected extramural venous invasion in rectal carcinoma.Clin Radiol. 2014; 69: 619-623
- MRI-detected extramural vascular invasion is an independent prognostic factor for synchronous metastasis in patients with rectal cancer.Eur Radiol. 2014;
- The Relationship Between MR Demonstration of Extramural Venous Invasion and Nodal Disease in Rectal Cancer.Clin Med Oncol. 2008; 2: 267-273
- Risk factors of nodal involvement in T2 colorectal cancer.Dis Colon Rectum. 2010; 53: 1393-1399
- Location of involved mesorectal and extramesorectal lymph nodes in patients with primary rectal cancer: preoperative assessment with MR imaging.Eur J Surg Oncol. 2008; 34: 776-781
- Evidence for radiologic and histopathologic prognostic importance of detecting EMVI in rectal cancer: recommendations for radiology and histopathology reporting.Color Dis. 2015; 17: 468-473
Article info
Publication history
Published online: January 22, 2016
Accepted:
January 15,
2016
Received in revised form:
January 7,
2016
Received:
September 2,
2015
Footnotes
☆This work was supported by the Health Industry Special Scientific Research Project from National Health and Family Planning Commission of China (No. 201402019).
☆☆Conflicts of interest: None.
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
