Abstract
Purpose
To evaluate the potential of intravoxel incoherent motion (IVIM) imaging to predict
histological prognostic parameters by investigating whether IVIM parameters correlate
with Gleason score.
Materials and methods
The institutional review board approved this retrospective study, and informed consent
was waived. A total of 41 patients with histologically proven prostate cancer who
underwent prostate MRI using a 3 T MRI machine were included. For eight diffusion-weighted imaging b-values (0, 10,
20, 50, 100, 200, 500, and 800 s/mm2), a spin-echo echo-planar imaging sequence was performed. D, f, D⁎, and ADCfit values were compared among three groups of patients with prostate cancer: Gleason
score 6 (n=9), 7 (n=16), or 8 or higher (n=16). Receiver operating characteristic (ROC) curves were generated for D, f, D⁎, and ADCfit to assess the ability of each parameter to distinguish cancers with low Gleason scores
from cancers with intermediate or high Gleason scores.
Results
Pearson's coefficient analysis revealed significant negative correlations between
Gleason score and ADCfit (r=−0.490, P=.001) and Gleason score and D values (r=−0.514, P=.001). Gleason score was poorly correlated with f (r=0.168, P=.292) and D⁎ values (r=−0.108, P=.500). The ADCfit and D values of prostate cancers with Gleason scores 7 or ≥8 were significantly lower than values for prostate cancers with Gleason score 6 (P<.05). ROC curves were constructed to assess the ability of IVIM parameters to discriminate
prostate cancers with Gleason score 6 from cancers with Gleason scores 7 or ≥8. Areas under the curve were 0.671 to 0.974. ADCfit and D yielded the highest Az value (0.960–0.956), whereas f yielded the lowest Az value (0.633).
Conclusions
The pure molecular diffusion parameter, D, was the IVIM parameter that best discriminated prostate cancers with low Gleason
scores from prostate cancers with intermediate or high Gleason scores.
Keywords
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Article info
Publication history
Published online: January 08, 2016
Accepted:
January 6,
2016
Received in revised form:
December 4,
2015
Received:
October 13,
2015
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
