Abstract
Purpose
The purpose was to investigate the correlation between epicardial adipose tissue (EAT)
thickness, EAT volume, and severity of coronary artery stenosis.
Methods
We retrospectively enrolled 188 patients that underwent coronary computed tomography
(CT) angiography for clinically suspected coronary artery disease using 64-MDCT. Images
were reconstructed using a retrospective electrocardiogram-gated algorithm with 0.625-mm-thick
sections. EAT thickness and volume were calculated.
Results
The coronary CT angiography showed 106 patients who had coronary artery pathology
(178 lesions), 21 patients with moderate stenosis (27 lesions), 12 patients with severe
stenosis (18 lesions), and 6 patients with complete occlusion (8 lesions). EAT thickness,
EAT volume, and Gensini score were statistically different among groups (FT=32.306, FV=27.743, F=110.483, P=.000). Pearson correlation analysis showed that Gensini score had significantly positive
correlation with EAT thickness and volume, respectively.
Conclusion
EAT thickness and volume demonstrated a positive correlation with severity of coronary
artery stenosis.
Keywords
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References
- Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties.Comp Biochem Physiol B. 1989; 94: 225-232
- Visceral fat accumulation as a predictor of coronary artery calcium as assessed by multislice computed tomography in Japanese patients.Atherosclerosis. 2009; 202: 192-199
- Visceral adipose tissue area is associated with coronary stenosis and noncalcified plaques.Int J Obes. 2014; 38: 272-278
- Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study.Circulation. 2008; 117: 605-613
- Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis.Clin Endocrinol. 2009; 70: 876-882
- Relations of epicardial adipose tissue measured by multidetector computed tomography to components of the metabolic syndrome are region-specific and independent of anthropometric indexes and intraabdominal visceral fat.J Clin Endocrinol Metab. 2009; 94: 662-669
- How to interpret epicardial adipose tissue as a cause of coronary artery disease: a meta-analysis.Coron Artery Dis. 2012; 23: 227-233
- Relationship between epicardial fat measured by 64-multidetector computed tomography and coronary artery disease.Clin Cardiol. 2011; 34: 166-171
- A more meaningful scoring system for determining the severity of coronary heart disease.Am J Cardiol. 1983; 51: 606
- Automated quantification of epicardial adipose tissue (EAT) in coronary CT angiography; comparison with manual assessment and correlation with coronary artery disease.J Cardiovasc Comput Tomogr. 2014; 8: 215-221
- Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease.Cardiovasc Diabetol. 2006; 5: 1
- Echocardiographic epicardial fat thickness and coronary artery disease.Circ J. 2007; 71: 536-539
- Effect of obesity on coronary artery plaque using 64 slice multidetector cardiac computed tomography angiography.Int J Cardiol. 2010; 140: 358-360
- Left ventricular apex involvement in hypertrophic cardiomyopathy.Echocardiography. 2015;
- Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis.Arterioscler Thromb Vasc Biol. 2009; 29: 781-786
- Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction.Obes Res. 2003; 11: 304-310
- Epicardial adipose tissue volume and cardiovascular disease in hemodialysis patients.Atherosclerosis. 2013; 226: 129-133
Article info
Publication history
Published online: December 17, 2015
Accepted:
December 15,
2015
Received in revised form:
November 23,
2015
Received:
July 20,
2015
Footnotes
Author contributions:
Guarantor of integrity of the entire study: Yunfei Zha.
Study concepts and design: Chunying Yang, Liang Li, and Yunfei Zha.
Literature research: Chunying Yang and Zhoufeng Peng.
Clinical studies: Chunying Yang and Liang Li.
Experimental studies/data analysis: Chunying Yang.
Statistical analysis: Chunying Yang.
Manuscript preparation: Chunying Yang.
Manuscript editing: Chunying Yang and Yunfei Zha.
Conflict of interests: The authors declare that there is no conflict of interests regarding the publication of this paper.
Identification
Copyright
© 2015 Elsevier Inc. All rights reserved.
