Advertisement

Correlation between epicardial adipose tissue and severity of coronary artery stenosis evaluated by 64-MDCT

Published:December 17, 2015DOI:https://doi.org/10.1016/j.clinimag.2015.12.003

      Abstract

      Purpose

      The purpose was to investigate the correlation between epicardial adipose tissue (EAT) thickness, EAT volume, and severity of coronary artery stenosis.

      Methods

      We retrospectively enrolled 188 patients that underwent coronary computed tomography (CT) angiography for clinically suspected coronary artery disease using 64-MDCT. Images were reconstructed using a retrospective electrocardiogram-gated algorithm with 0.625-mm-thick sections. EAT thickness and volume were calculated.

      Results

      The coronary CT angiography showed 106 patients who had coronary artery pathology (178 lesions), 21 patients with moderate stenosis (27 lesions), 12 patients with severe stenosis (18 lesions), and 6 patients with complete occlusion (8 lesions). EAT thickness, EAT volume, and Gensini score were statistically different among groups (FT=32.306, FV=27.743, F=110.483, P=.000). Pearson correlation analysis showed that Gensini score had significantly positive correlation with EAT thickness and volume, respectively.

      Conclusion

      EAT thickness and volume demonstrated a positive correlation with severity of coronary artery stenosis.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Clinical Imaging
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Marchington JM
        • Mattacks CA
        • Pond CM
        Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties.
        Comp Biochem Physiol B. 1989; 94: 225-232
        • Ohashi N
        • Yamamoto H
        • Horiguchi J
        • Kitagawa T
        • Hirai N
        • Ito K
        • et al.
        Visceral fat accumulation as a predictor of coronary artery calcium as assessed by multislice computed tomography in Japanese patients.
        Atherosclerosis. 2009; 202: 192-199
        • Kang SJ
        • Kim D
        • Park HE
        • Choi SH
        • Choi SY
        • Lee W
        • et al.
        Visceral adipose tissue area is associated with coronary stenosis and noncalcified plaques.
        Int J Obes. 2014; 38: 272-278
        • Rosito GA
        • Massaro JM
        • Hoffmann U
        • Ruberg FL
        • Mahabadi AA
        • Vasan RS
        • et al.
        Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study.
        Circulation. 2008; 117: 605-613
        • Wang CP
        • Hsu HL
        • Hung WC
        • Yu TH
        • Chen YH
        • Chiu CA
        • et al.
        Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis.
        Clin Endocrinol. 2009; 70: 876-882
        • Wang TD
        • Lee WJ
        • Shih FY
        • Huang CH
        • Chang YC
        • Chen WJ
        • et al.
        Relations of epicardial adipose tissue measured by multidetector computed tomography to components of the metabolic syndrome are region-specific and independent of anthropometric indexes and intraabdominal visceral fat.
        J Clin Endocrinol Metab. 2009; 94: 662-669
        • Xu Y
        • Cheng X
        • Hong K
        • Huang C
        • Wan L
        How to interpret epicardial adipose tissue as a cause of coronary artery disease: a meta-analysis.
        Coron Artery Dis. 2012; 23: 227-233
        • Iwasaki K
        • Matsumoto T
        • Aono H
        • Furukawa H
        • Samukawa M
        Relationship between epicardial fat measured by 64-multidetector computed tomography and coronary artery disease.
        Clin Cardiol. 2011; 34: 166-171
        • Gensini GG
        A more meaningful scoring system for determining the severity of coronary heart disease.
        Am J Cardiol. 1983; 51: 606
        • Mihl C
        • Loeffen D
        • Versteylen MO
        • Takx RA
        • Nelemans PJ
        • Nijssen EC
        • et al.
        Automated quantification of epicardial adipose tissue (EAT) in coronary CT angiography; comparison with manual assessment and correlation with coronary artery disease.
        J Cardiovasc Comput Tomogr. 2014; 8: 215-221
        • Baker AR
        • Silva NF
        • Quinn DW
        • Harte AL
        • Pagano D
        • Bonser RS
        • et al.
        Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease.
        Cardiovasc Diabetol. 2006; 5: 1
        • Jeong JW
        • Jeong MH
        • Yun KH
        • Oh SK
        • Park EM
        • Kim YK
        • et al.
        Echocardiographic epicardial fat thickness and coronary artery disease.
        Circ J. 2007; 71: 536-539
        • Isma'eel H
        • Tellalian D
        • Hamirani YS
        • Kadakia J
        • Nasir K
        • Budoff MJ
        Effect of obesity on coronary artery plaque using 64 slice multidetector cardiac computed tomography angiography.
        Int J Cardiol. 2010; 140: 358-360
        • Parato VM
        • Olivotto I
        • Maron MS
        • Nanda NC
        • Pandian NG
        Left ventricular apex involvement in hypertrophic cardiomyopathy.
        Echocardiography. 2015;
        • Greif M
        • Becker A
        • von Ziegler F
        • Lebherz C
        • Lehrke M
        • Broedl UC
        • et al.
        Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis.
        Arterioscler Thromb Vasc Biol. 2009; 29: 781-786
        • Iacobellis G
        • Assael F
        • Ribaudo MC
        • Zappaterreno A
        • Alessi G
        • Di Mario U
        • et al.
        Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction.
        Obes Res. 2003; 11: 304-310
        • Turan MN
        • Gungor O
        • Asci G
        • Kircelli F
        • Acar T
        • Yaprak M
        • et al.
        Epicardial adipose tissue volume and cardiovascular disease in hemodialysis patients.
        Atherosclerosis. 2013; 226: 129-133