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Comparison of high-resolution T1W 3D GRE (LAVA) with 2-point Dixon fat/water separation (FLEX) to T1W fast spin echo (FSE) in prostate cancer (PCa)

Published:December 03, 2015DOI:https://doi.org/10.1016/j.clinimag.2015.11.023

      Abstract

      Purpose

      To compare T1-weighted (T1W) fast spin echo (FSE) to T1W 3-dimensional gradient recalled echo (LAVA) with fat water separation (FLEX) in prostate cancer (PCa).

      Methodology

      With institutional review board waiver, 39 patients underwent 3-T magnetic resonance imaging including T1W LAVA FLEX (157 s)/T1W FSE (316 s). Two radiologists assessed (a) image quality/sharpness, (b) presence/severity of artifacts, and (c) skeletal (N=22)/nodal (N=9) metastases. Results were compared using Wilcoxon signed-rank test/receiver operator characteristic analysis.

      Results

      With T1W LAVA FLEX, image quality/sharpness improved (P<.001) with less motion (P=.002–.03) and no difference in phase-encoding artifact (P>.05). One patient had moderate fat/water swap.
      Detection of skeletal metastases was unchanged (P>.05) and nodal metastases either improved (P=.002) or were comparable (P=.16) using T1W LAVA FLEX.

      Conclusion

      T1W LAVA FLEX improves image quality, lessens motion artifact, and is comparable or improves detection of metastases in PCa with reduction in acquisition time.

      Keywords

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