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Bone marrow cellularity MRI calculation and correlation with bone marrow biopsy

Published:December 02, 2015DOI:https://doi.org/10.1016/j.clinimag.2015.11.018

      Abstract

      Purpose

      To calculate bone marrow cellularity from MRI and correlate with bone marrow biopsy.

      Methods

      Twenty-seven lymphoma patients with staging bone marrow biopsies and lumbar MRI were reviewed. Cellularity was calculated from T1 signal intensity measurements=100 – {[(marrow – CSF)/(subcutaneous fat – CSF)] X 100}.

      Results

      The histologic cellularities demonstrated significant correlation with iliac bone MRI cellularity (r=0.59, P=.001). Cellularities increased from T11 to S1. Cellularity decreased with age=67.6 – (age X 0.36).

      Conclusions

      Marrow cellularity from MRI shows statistically significant correlation with biopsy and significant differences between vertebral levels and changes with age.

      Keywords

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