CT perfusion imaging of the stomach: a quantitative analysis according to different degrees of adenocarcinoma cell differentiation

Published:November 20, 2015DOI:



      To evaluate clinical usefulness of computed tomography perfusion imaging (CTPI) in gastric cancer.

      Materials and methods

      Twenty subjects without gastric diseases (control group) and fifty patients with gastric cancer were studied prospectively using CTPI examinations. Four perfusion parameter values, i.e., blood flow (BF), blood volume (BV), mean transit time, and permeability surface (PS), were calculated. The gastric cancer group was divided into three groups: well differentiated, moderately differentiated, and poorly differentiated gastric adenocarcinoma.


      Comparing the three groups, differences between the well-differentiated group and the moderately differentiated group or the poorly differentiated group were all statistically significant for BF, BV, and PS.


      The BF, BV, and PS values could serve as indicators of the degree of malignancy of gastric cancer.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Clinical Imaging
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Lee SJ
        • Lee WW
        • Yoon HJ
        • Lee HY
        • Lee KH
        • Kim YH
        • et al.
        Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer.
        Eur J Radiol. 2013; 82: 935-942
        • Wong BC
        • Lam SK
        • Wong WM
        • Chen JS
        • Zheng TT
        • Feng RE
        • et al.
        Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.
        JAMA. 2004; 291: 187-194
        • Yan SY
        • Hu Y
        • Fan JG
        • Tao GQ
        • Lu YM
        • Cai X
        • et al.
        Clinicopathologic significance of HER-2/neu protein expression and gene amplification in gastric carcinoma.
        World J Gastroenterol. 2011; 17: 1501-1506
        • Bang YJ
        • Kang YK
        • Kang WK
        • Boku N
        • Chung HC
        • Chen JS
        • et al.
        Phase II study of sunitinib as second-line treatment for advanced gastric cancer.
        Investig New Drugs. 2011; 29: 1449-1458
        • Kim SK
        • Kang KW
        • Lee JS
        • Kim HK
        • Chang HJ
        • Choi JY
        • et al.
        Assessment of lymph node metastases using 18F-FDG PET in patients with advanced gastric cancer.
        Eur J Nucl Med Mol Imaging. 2006; 33: 148-155
        • Yeung HW
        • Macapinlac H
        • Karpeh M
        • Finn RD
        • Larson SM
        Accuracy of FDG-PET in gastric cancer. Preliminary experience.
        Clin Positron Imaging. 1998; 1: 213-221
        • Miles KA
        • Hayball M
        • Dixon AK
        Colour perfusion imaging: a new application of computed tomography.
        Lancet. 1991; 337: 643-645
        • Miles KA
        Measurement of tissue perfusion by dynamic computed tomography.
        Br J Radiol. 1991; 64: 409-412
        • Bivard A
        • Levi C
        • Spratt N
        • Parsons M
        Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra.
        Radiology. 2013; 267: 543-550
        • Miles KA
        • Griffiths MR
        Perfusion CT: a worthwhile enhancement?.
        Br J Radiol. 2003; 76: 220-231
        • Su BY
        • Jin ZY
        • Liu W
        • Sun H
        • Wang X
        • Chen Y
        • et al.
        Features of eight segments of liver perfusion with the second generation dual-source computed tomography.
        Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2010; 32: 655-658
        • Li HO
        • Sun C
        • Xu ZD
        • Miao F
        • Zhang DJ
        • Chen JH
        • et al.
        Low-dose whole organ CT perfusion of the pancreas: preliminary study.
        Abdom Imaging. 2014; 39: 40-47
        • Klau M
        • Stiller W
        • Fritz F
        • Kieser M
        • Werner J
        • Kauczor HU
        • et al.
        Computed tomography perfusion analysis of pancreatic carcinoma.
        J Comput Assist Tomogr. 2012; 36: 237-242
        • Li P
        • Gao JB
        • Yue SW
        • Zhang YG
        • Yang XH
        Preliminary evaluation of 64 slice spiral CT perfusion imaging in stomach neoplasm.
        J Pract Radiol. 2011; 27: 552-555
        • Yao J
        • Yang ZG
        • Chen HJ
        • Chen TW
        • Huang J
        Gastric adenocarcinoma: can perfusion CT help to noninvasively evaluate tumor angiogenesis?.
        Abdom Imaging. 2011; 36: 15-21
        • Satoh A
        • Shuto K
        • Okazumi S
        • Ohira G
        • Natsume T
        • Hayano K
        • et al.
        Role of perfusion CT in assessing tumor blood flow and malignancy level of gastric cancer.
        Dig Surg. 2010; 27: 253-260
        • Zhang LJ
        • Jiang B
        • Shen W
        Perfusion CT of stomach: initial experiences.
        Radiol Pract. 2007; 22: 830-832
        • Goh V
        • Halligan S
        • Wellsted DM
        • Bartram CI
        Can perfusion CT assessment of primary colorectal adenocarcinoma blood flow at staging predict for subsequent metastatic disease? A pilot study.
        Eur Radiol. 2009; 19: 79-89
        • Zhang H
        • Pan Z
        • Du L
        • Yan C
        • Ding B
        • Song Q
        • et al.
        Advanced gastric cancer and perfusion imaging using a multidetector row computed tomography: correlation with prognostic determinants.
        Korean J Radiol. 2008; 9: 119-127