Hypertrophic olivary degeneration resulting from posterior fossa masses and their treatments



      Characterize hypertrophic olivary degeneration (HOD) that develops from posterior fossa masses and their treatments.


      Retrospectively reviewed MR images and clinical data of 10 patients with posterior fossa masses and HOD.


      Eight patients had cerebellar lesions, and two patients had pontine lesions. Lesions consisted of tumors, demyelination, and nonspecific necrosis. MRI showed T2 hyperintense signal in the inferior olive a median 86 days after the diagnosis of a posterior fossa lesion. HOD presented prior to surgery (n=2), after surgery (n=3), after surgery/radiation therapy (n=4), or without treatment (n=1).


      HOD may develop from posterior fossa masses and surgical and/or radiation therapy.


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        • Gautier JC
        • Blackwood W
        Enlargement of the inferior olivary nucleus in association with lesions of the central tegmental tract or dentate nucleus.
        Brain. 1961; 84: 341-361
        • Goyal M
        • Versnick E
        • Tuite P
        • Cyr JS
        • Kucharczyk W
        • Montanera W
        • et al.
        Hypertrophic olivary degeneration: metaanalysis of the temporal evolution of MR findings.
        AJNR Am J Neuroradiol. 2000; 21: 1073-1077
        • Hornyak M
        • Osborn AG
        • Couldwell WT
        Hypertrophic olivary degeneration after surgical removal of cavernous malformations of the brain stem: report of four cases and review of the literature.
        Acta Neurochir (Wien). 2008; 150 ([discussion 56]): 149-156
        • Krings T
        • Foltys H
        • Meister IG
        • Reul J
        Hypertrophic olivary degeneration following pontine haemorrhage: hypertensive crisis or cavernous haemangioma bleeding?.
        J Neurol Neurosurg Psychiatry. 2003; 74: 797-799
        • Phatouros CC
        • McConachie NS
        Hypertrophic olivary degeneration: case report in a child.
        Pediatr Radiol. 1998; 28: 830-831
        • Litkowski P
        • Young RJ
        • Wolden SL
        • Souweidane MM
        • Haque S
        • Gilheeney SW
        Collision in the inferior olive: hypertrophic olivary degeneration complicated by radiation necrosis in brainstem primitive neuroendocrine tumor.
        Clin Imaging. 2012; 36: 371-374
        • Kitajima M
        • Korogi Y
        • Shimomura O
        • Sakamoto Y
        • Hirai T
        • Miyayama H
        • et al.
        Hypertrophic olivary degeneration: MR imaging and pathologic findings.
        Radiology. 1994; 192: 539-543
        • Sanverdi SE
        • Oguz KK
        • Haliloglu G
        Hypertrophic olivary degeneration in children: four new cases and a review of the literature with an emphasis on the MRI findings.
        Br J Radiol. 2012; 85: 511-516
        • Shinohara Y
        • Kinoshita T
        • Kinoshita F
        • Kaminou T
        • Watanabe T
        • Ogawa T
        Hypertrophic olivary degeneration after surgical resection of brain tumors.
        Acta Radiol. 2013; 54: 462-466
        • Shah R
        • Markert J
        • Bag AK
        • Cure JK
        Diffusion tensor imaging in hypertrophic olivary degeneration.
        AJNR Am J Neuroradiol. 2010; 31: 1729-1731