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Differentiation of true-progression from pseudoprogression in glioblastoma treated with radiation therapy and concomitant temozolomide by GLCM texture analysis of conventional MRI

  • Author Footnotes
    1 Equal contribution, co-first authors.
    Xin Chen
    Footnotes
    1 Equal contribution, co-first authors.
    Affiliations
    Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, 602 Ren Min Bei Road, Guangzhou 510180, China
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  • Author Footnotes
    1 Equal contribution, co-first authors.
    Xinhua Wei
    Footnotes
    1 Equal contribution, co-first authors.
    Affiliations
    Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, 602 Ren Min Bei Road, Guangzhou 510180, China
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  • Zhongping Zhang
    Affiliations
    GE Healthcare China, Guangzhou, 510080, China
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  • Ruimeng Yang
    Affiliations
    Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, 602 Ren Min Bei Road, Guangzhou 510180, China
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  • Yanjie Zhu
    Correspondence
    Corresponding author. Y. Zhu, Shenzhen Institutes of Advanced Technology, Shenzhen, 518055, China. Tel/fax: +86 755 86392245.
    Affiliations
    Shenzhen Institutes of Advanced Technology, Shenzhen, 518055, China
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  • Xinqing Jiang
    Correspondence
    Corresponding author. X. Jiang, Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, Guangzhou, 510180, China. Tel/fax: +86 20 83992090.
    Affiliations
    Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, 602 Ren Min Bei Road, Guangzhou 510180, China
    Search for articles by this author
  • Author Footnotes
    1 Equal contribution, co-first authors.

      Abstract

      Twenty-two patients with pathologically confirmed glioblastoma who had received concurrent CCRT with TMZ underwent conventional MRI including T1-weighted imaging(T1WI), T2-weighted imaging(T2WI), fluid attenuated inversion recovery(FLAIR)and contrast-enhanced T1WI(T1Ce). Five GLCM texture maps of contrast, energy, entropy, correlation and homogeneity were generated for each MRI series. Of the aforementioned 5 texture features, the most significant features were contrast and correlation on T2WI with areas under ROC curve of 0.883 and 0.892, respectively, and they had the same sensitivity of 75%, specificity of 100%, accuracy of 86.4%, PPV of 100% and NPV of 76.9% in differentiation true progression from pseudoprogression.

      Keywords

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