Advertisement

Multimodality imaging of Epstein–Barr virus-associated inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen: case report and literature review

  • Author Footnotes
    1 Present address: 3900 Junius St. Suite 100 Dallas, TX 75246.
    Pauline L. Bui
    Correspondence
    Corresponding author. Department of Diagnostic Radiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Tel.: +214-820-9227.
    Footnotes
    1 Present address: 3900 Junius St. Suite 100 Dallas, TX 75246.
    Affiliations
    Department of Diagnostic Radiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030
    Search for articles by this author
  • Rafael A. Vicens
    Affiliations
    Department of Diagnostic Radiology, Unit 1473, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030–4009
    Search for articles by this author
  • Jason R. Westin
    Affiliations
    Department of Lymphoma/Myeloma, Unit 0429, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030–4009
    Search for articles by this author
  • Author Footnotes
    2 Tel.: +1 713 745 3835; fax: +1 713 745 1152.
    Corey T. Jensen
    Footnotes
    2 Tel.: +1 713 745 3835; fax: +1 713 745 1152.
    Affiliations
    Department of Diagnostic Radiology, Unit 1473, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030–4009
    Search for articles by this author
  • Author Footnotes
    1 Present address: 3900 Junius St. Suite 100 Dallas, TX 75246.
    2 Tel.: +1 713 745 3835; fax: +1 713 745 1152.

      Abstract

      Inflammatory pseudotumors (IPTs) are rare tumors of unknown etiology; however, there is a strong association with the Epstein–Barr virus (EBV). EBV-positive IPTs are typically found in the liver and spleen. While many EBV-positive splenic IPTs contain follicular dendritic cell (FDC) proliferations, they are not aggressive such as with conventional FDC tumors. EBV-positive splenic IPTs have been reported with low malignant potential. We present a case with multimodality imaging of an EBV-positive IPT-like tumor with FDC features.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Clinical Imaging
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Okura N
        • Mori K
        • Morishita Y
        • Oda T
        • Tanoi T
        • Minami M
        Inflammatory pseudotumor of the intrapancreatic accessory spleen: computed tomography and magnetic resonance imaging findings.
        Jpn J Radiol. 2012; 30: 171-175
        • Rosenbaum L
        • Fekrazad MH
        • Rabinowitz I
        • Vasef M.A.
        Epstein-Barr virus-associated inflammatory pseudotumor of the spleen: report of two cases and review of the literature.
        J Hematop. 2009; 2: 127-131
        • Kiryu S
        • Takeuchi K
        • Shibahara J
        • Uozaki H
        • Fukayama M
        • Tanaka H
        • et al.
        Epstein-Barr virus-positive inflammatory pseudotumour and inflammatory pseudotumour-like follicular dendritic cell tumour.
        Br J Radiol. 2009; 82: e67-e71
        • Vardas K
        • Mangnas D
        • Papadimitriou G
        • Kalatzis V
        • Kyriakopoulos G
        • Chantziara M.
        • et al.
        Splenic inflammatory pseudotumor-like follicular dendritic cell tumor case report.
        Oncology. 2014; 7: 410-416
        • Lewis J
        • Gaffney R
        • Casey M
        • Farrell M
        • Morice W
        • Macon W
        Inflammatory pseudotumor of the spleen associated with a clonal Epstein-Barr Virus Genome.
        Am J Clin Pathol. 2003; 120: 56-61
        • Arber D
        • Kamel O
        • van de Rijn M
        • Davis E
        • Medeiros J
        • Jaffe E
        • Weiss L
        Frequent presence of the Epstein-Barr Virus in inflammatory pseudotumor.
        Hum Pathol. 1995; 26: 1093-1098
        • Cheuk W
        • Chan J
        • Shek T
        • Chang J
        • Tsou M
        • Yuen N
        • et al.
        Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association.
        Am J Surg Pathol. 2001; 25: 721-731
        • Yarmohammadi H
        • Nakamoto D
        • Faulhaber P
        • Miedler J
        • Azar N
        Inflammatory pseudotumor of the spleen: review of clinical presentation and diagnostic methods.
        J Radiol. 2011; 5: 16-22
        • Yamaguchi M
        • Yamamoto T
        • Tate G
        • Matsumoto T
        • Matsumiya A
        • Kuzume M
        • et al.
        Specific detection of Epstein-Barr virus in inflammatory pseudotumor of the spleen in a patient with a high serum level of soluble IL-2 receptor.
        J Gastroenterol. 2000; 35: 563-566
        • Oz Puyan F
        • Bilgi S
        • Unlu E
        • Yalcin O
        • Altaner S
        • Demir M
        • et al.
        Inflammatory pseudotumor of the spleen with EBV positivity: report of a case.
        Eur J Haematol. 2004; 72: 285-291
        • Glazer M
        • Lally J
        • Kanzer M
        Case report: inflammatory pseudotumor of the spleen: MR findings.
        J Comput Assist Tomogr. 1992; 16: 980-983
        • Hsu C
        • Lin C
        • Yang T
        • Chang H
        Splenic inflammatory pseudotumor mimicking angiosarcoma.
        World J Gastroenterol. 2008; 14: 6421-6424
        • Yamakado K
        • Matsuda A
        • Katoh N
        • Hirano T
        • Takeda K
        • Nakagawa T
        Inflammatory pseudotumour of the spleen: CT and MRI findings.
        Eur Radiol. 1994; 4: 271-273
        • Rao L
        • Yung Z
        • Wang X
        • Zhang X
        • Shen B
        Imaging findings of inflammatory pseudotumor-like follicular dendritic cell tumor of spleen.
        Clin Nucl Med. 2014; 39: e286-e289
        • Bhatt S
        • Simon R
        • Dogra V
        Radiologic-Pathologic conferences of the University of Rochester School of Medicine: inflammatory pseudotumor of the spleen.
        Am J Radiol. 2008; 191: 1477-1479
        • Rabushka L
        • Kawashima A
        • Fishman E
        Imaging of the spleen: CT with supplemental MR examination.
        RadioGraphics. 1994; 14: 307-332
        • Horiguchi H
        • Matsui-Horiguchi M
        • Sakata H
        • Ichinose M
        • Yamamoto T
        • Fujiwara M
        • et al.
        Inflammatory pseudotumor-like follicular dendritic cell tumor of the spleen.
        Pathol Int. 2004; 54: 124-131