Abstract
Purpose
The purpose of this study was to retrospectively evaluate symptoms, images of salivary
gland dysfunction, and related clinical factors in thyroid cancer patients with total
thyroidectomy followed by radioiodine therapy (RIT).
Methods
We included 164 patients who underwent thyroid ultrasonography or contrast-enhanced
neck computed tomography more than 6 months later after RIT. Correlation between subjective
symptoms and various RIT doses was also evaluated.
Results
Swelling and decreased salivary volume were the most common symptoms and images. RIT
dose was the only factor with a positive correlation (P<.001).
Conclusion
The dose of RIT should be carefully determined to minimize gland dysfunction.
Keywords
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References
- Papillary and follicular thyroid carcinoma.N Engl J Med. 1998; 338: 297-306
- Strategies of radioiodine ablation in patients with low-risk thyroid cancer.N Engl J Med. 2012; 366: 1663-1673
- Intermediate and long-term side effects of high-dose radioiodine therapy for thyroid carcinoma.J Nucl Med. 1998; 39: 1551-1554
- 99mTc-pertechnetate uptake in parotid acinar cells by the Na+/K+/Cl− co-transport system.J Clin Invest. 1987; 79: 1310-1313
- The role of radioactive iodine in salivary gland dysfunction.Ear Nose Throat J. 2000; 79: 460-468
- Imaging the major salivary glands.Br J Oral Maxillofac Surg. 2011; 49: 261-269
- Radioactive iodine and the salivary glands.Thyroid. 2003; 13: 265-271
- Quantitative evaluation of salivary gland dysfunction after radioiodine therapy using salivary gland scintigraphy.Nucl Med Commun. 2006; 27: 495-499
- Scintigraphic evaluation of salivary gland dysfunction in patients with thyroid cancer after radioiodine treatment.Clin Nucl Med. 2002; 27: 767-771
- Salivary and lacrimal gland dysfunction (sicca syndrome) after radioiodine therapy.J Nucl Med. 2001; 42: 738-743
- Acquired salivary dysfunction. Drugs and radiation.Ann N Y Acad Sci. 1998; 842: 132-137
- Salivary gland function 5 years after radioactive iodine ablation in patients with differentiated thyroid cancer: direct comparison of pre- and postablation scintigraphies and their relation to xerostomia symptoms.Thyroid. 2013; 23: 609-616
- Late side effects of radioactive iodine on salivary gland function in patients with thyroid cancer.Head Neck. 2011; 33: 686-690
- Assessment of salivary gland dysfunction after radioiodine therapy for thyroid carcinoma using non-contrast-enhanced CT: the significance of changes in volume and attenuation of the glands.AJNR. 2012; 33: 1964-1970
- Radionuclide diagnosis and therapy of thyroid cancer: current status report.Semin Nucl Med. 1985; 15: 106-131
- Sialadenitis following iodine-131 therapy for thyroid carcinoma.J Nucl Med. 1985; 26: 816-817
- Does lemon candy decrease salivary gland damage after radioiodine therapy for thyroid cancer?.J Nucl Med. 2005; 46: 261-266
Article info
Publication history
Published online: January 06, 2015
Accepted:
December 18,
2014
Received in revised form:
November 28,
2014
Received:
August 18,
2014
Footnotes
☆Funding sources: none.
☆☆Conflict of interest: none declared.
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.