Y90 radioembolization of colorectal cancer liver metastases: response assessment by contrast-enhanced computed tomography with or without PET-CT guidance



      To compare various computed tomography (CT) parameters to the positron emission tomography with computed tomography (PET-CT) response, with or without PET guidance for the response assessment of colorectal cancer (CRC) metastases treated by Y90 radioembolization.


      Thirty-six CRC metastases were retrospectively evaluated on 18F-Fluoro-Deoxy-Glucose PET-CT and contrast-enhanced computed tomography (CECT) performed at baseline and 2–3 months after Y90 radioembolization.


      Median SUVmax values decreased from 11.39 to 6.71 after radioembolization (P<.001), and 23/36 (64%) metastases were categorized metabolic responses according to European Organisation for Research and Treatment of Cancer criteria. Only a decrease of the mean attenuation in the structural (P<.001) and metabolic active volume (P<.001) was observed. The change in these criteria was correlated with the change of SUVmax.


      CEA (carcinoembryonic antigen), CRC (colorectal cancer), CECT (contrast-enhanced computed tomography), EORTC (European Organisation for Research and Treatment of Cancer), FDG (18F-Fluoro-Deoxyglucose), HU (Hounsfield unit), IQR (interquartile range), LDT (liver directed therapies), MAMAV (mean attenuation in the metabolic active volume), MASV (mean attenuation in the structural volume), MD (maximal diameter measured in the axial plane), PET(−CT) (positron emission tomography (with computed tomography)), RECIST (response criteria in solid tumors), S.D. (standard deviation), SPECT (single photon emission computed tomography), SUVmax (maximal standardized uptake value), SV (structural volume), 99Tc-MAA (99Technetium-macroaggregated albumin), VOI (volume of interest), Y90 (90Yttrium)


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