Abstract
Objective
The present study was to evaluate the clinical value of dual-energy computed tomography
(DECT) for detecting monosodium urate crystals in patients with gouty arthritis.
Methods
Two hundred and two patients, who experienced arthrocele and (or) joint pain, were
enrolled into our study. DECT scans of upper or lower extremity were performed. One
hundred and sixty one patients who conformed to the American College of Rheumatology
classification standard were defined as the gout group. The rest (41) of the patients
were regarded as the without-gout group. DE (80 kV/140 kV) datasets were reconstructed via DE gout software. Images were reviewed independently
by two senior radiologists.
Results
In the gout group, DECT scans revealed a total of 379 areas of urate deposition in
121 patients. In the without-gout group, 3 areas of green urate deposition were detected.
The sensitivity and specificity were 75.2% and 92.7%, respectively; when we increased
the ratio to 1.32 and decreased the range to 3, the number of patients with green
urate deposition increased, and the areas of urate deposition were more extensive.
The sensitivity and specificity were 91.9% and 85.4%. DECT images could illustrate
the palpable reduction in the tissue urate deposits compared to baseline images before
and after treatment.
Conclusions
DECT has comparable sensitivity and specificity for the detection of gouty arthritis
in a clinical setting, and DECT can monitor the clinical treatment. However, DECT
results should be interpreted carefully because there could be some false-negative
or false-positive findings.
Keywords
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Article info
Publication history
Published online: February 10, 2015
Accepted:
December 24,
2014
Received in revised form:
December 4,
2014
Received:
June 16,
2014
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
