Abstract
Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis.
It has been demonstrated that trabecular bone microstructure analysis improves the
prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral
density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular
bone microstructure parameters as advanced imaging biomarkers in subjects with ISM
(n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important
pathophysiological information about ISM-associated osteoporosis and may limit the
use of trabecular bone microstructure analysis in this clinical setting.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Mastocytosis: state of the art.Pathobiology. 2007; 74: 121-132
- Epidemiology, prognosis, and risk factors in mastocytosis.Immunol Allergy Clin North Am. 2014; 34: 283-295
- Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria.Eur J Clin Invest. 2007; 37: 435-453
- Bone involvement and osteoporosis in mastocytosis.Immunol Allergy Clin North Am. 2014; 34: 383-396
- High prevalence of fractures and osteoporosis in patients with indolent systemic mastocytosis.Allergy. 2012; 67: 431-438
- NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7–29, 2000: highlights of the conference.South Med J. 2001; 94: 569-573
- Health-related quality of life after vertebral or hip fracture: a seven-year follow-up study.BMC Musculoskelet Disord. 2009; 10: 135
- Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study.CMAJ. 2009; 181: 265-271
- An update on dual-energy x-ray absorptiometry.Semin Nucl Med. 2010; 40: 62-73
- Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study.Bone. 2004; 34: 195-202
- Zoledronic acid in osteoporosis secondary to mastocytosis.Am J Med. 2014; 127 (e1-4): 1127
- Osteoporosis imaging: state of the art and advanced imaging.Radiology. 2012; 263: 3-17
- High-resolution bone imaging for osteoporosis diagnostics and therapy monitoring using clinical MDCT and MRI.Curr Med Chem. 2013; 20: 4844-4852
- Reproducibility of trabecular bone structure measurements of the distal radius at 1.5 and 3.0T magnetic resonance imaging.J Comput Assist Tomogr. 2012; 36: 623-626
- Correlation of trabecular bone structure with age, bone mineral density, and osteoporotic status: in vivo studies in the distal radius using high resolution magnetic resonance imaging.J Bone Miner Res. 1997; 12: 111-118
- Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee.J Bone Miner Res. 1987; 2: 595-610
- Bone mineral density, bone turnover markers and fractures in patients with indolent systemic mastocytosis.Bone. 2011; 49: 880-885
- Predictors of new fragility fractures after diagnosis of indolent systemic mastocytosis.J Allergy Clin Immunol. 2014; 134: 1413-1421
- Gender differences in trabecular bone architecture of the distal radius assessed with magnetic resonance imaging and implications for mechanical competence.Osteoporos Int. 2005; 16: 1124-1133
- Cortical and trabecular bone structure analysis at the distal radius-prediction of biomechanical strength by DXA and MRI.J Bone Miner Metab. 2013; 31: 212-221
- The 3D-based scaling index algorithm: a new structure measure to analyze trabecular bone architecture in high-resolution MR images in vivo.Osteoporos Int. 2006; 17: 1483-1493
Article info
Publication history
Published online: December 11, 2014
Accepted:
December 8,
2014
Received in revised form:
November 30,
2014
Received:
November 5,
2014
Footnotes
☆Conflict of Interest: The authors state no conflict of interest.
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
