Abstract
Purpose
To assess the intraobserver reproducibility of shear wave elastography (SWE) in the
prostate.
Materials and methods
This study was institutional review board approved with waiver of informed consent.
Eighty men (mean age, 66.2±9.2 years) with suspected prostate cancer underwent SWE. Young modulus (kPa) was measured
at 24 locations in the prostate (superficial and deep locations in paramedian and
lateral aspects at the base, mid-gland, and apex levels). The intraobserver reproducibility
of two repeated measurements was determined using intraclass correlation coefficients
(ICC) and was compared among measurement location, prostate volume, age, and prostate-specific
antigen level.
Results
The overall intraobserver reproducibility was excellent (ICC=0.876). In addition,
intraobserver reproducibility was excellent for all specified subgroups according
to location, prostate volume, and clinical variables (ICC=0.826–0.917). With regard
to location, SWE measurements showed substantially higher ICC values in the mid-gland
than in the base and apex, in the paramedian prostate than in the lateral prostate,
and in superficial locations than in deeper locations. No substantial differences
in ICC values were observed according to the prostate volume and clinical variables.
Conclusion
Intraobserver reproducibility of SWE measurements in the prostate gland was excellent.
There was variability in the intraobserver reproducibility according to location within
the prostate, and the operator should be aware of this and take extra caution when
performing SWE in these areas.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Cancer statistics, 2009.CA Cancer J Clin. 2009; 59: 225-249
- Radical prostatectomy versus watchful waiting in early prostate cancer.N Engl J Med. 2005; 352: 1977-1984
- Formalized prediction of clinically significant prostate cancer: is it possible?.Asian J Androl. 2012; 14: 349-354
- Prostate cancer detection in men with serum PSA concentrations of 2.6 to 4.0 ng/mL and benign prostate examination. Enhancement of specificity with free PSA measurements.JAMA. 1997; 277: 1452-1455
- Challenges in clinical prostate cancer: role of imaging.AJR Am J Roentgenol. 2009; 192: 1455-1470
- Predictors of prostate cancer after initial negative systematic 12 core biopsy.J Urol. 2004; 171: 1850-1854
- Prospective evaluation of a 21-sample needle biopsy procedure designed to improve the prostate cancer detection rate.Urology. 2003; 61: 1181-1186
- Systematic 5 region prostate biopsy is superior to sextant method for diagnosing carcinoma of the prostate.J Urol. 1997; 157 ([discussion −3]): 199-202
- Contrast-enhanced ultrasonography using cadence-contrast pulse sequencing technology for targeted biopsy of the prostate.BJU Int. 2009; 103: 458-463
- Update on ultrasound elastography: miscellanea. Prostate, testicle, musculo-skeletal.Eur J Radiol. 2013; 82: 1904-1912
- Elastographic imaging.Ultrasound Med Biol. 2000; 26: S23-S29
- Sonographic breast elastography: a primer.J Ultrasound Med. 2012; 31: 773-783
- Shear wave ultrasound elastography of the prostate: initial results.Ultrasound Q. 2012; 28: 13-20
- Transrectal quantitative shear wave elastography in the detection and characterisation of prostate cancer.Surg Endosc. 2013; 27: 3280-3287
- Shear wave elastography for detection of prostate cancer: a preliminary study.Korean J Radiol. 2014; 15: 346-355
- Quantitative assessment of normal soft-tissue elasticity using shear-wave ultrasound elastography.AJR Am J Roentgenol. 2011; 197: 532-536
- Ultrasound elastography of the prostate: state of the art.Diagn Interv Imaging. 2013; 94: 551-560
- Elasticity as a biomarker for prostate cancer: a systematic review.BJU Int. 2014; 113: 523-534
- Impact of bent distortion on accuracy of measurement during transrectal ultrasonography for prostatic imaging: a preliminary study.Urology. 2013; 81: 915-919
- Shear-wave elastography in the diagnosis of solid breast masses: what leads to false-negative or false-positive results?.Eur Radiol. 2013; 23: 2432-2440
- Intra-observer reproducibility and diagnostic performance of breast shear-wave elastography in Asian women.Ultrasound Med Biol. 2014; 40: 1058-1064
- Significant changes in transrectal ultrasonic measurements of the prostate in relation to the degree of rectal wall distension.Ultrasound Med Biol. 2000; 26: 29-34
- Ultrasound point shear wave elastography assessment of liver and spleen stiffness: effect of training on repeatability of measurements.Eur Radiol. 2014; 24: 1283-1289
Article info
Publication history
Published online: November 21, 2014
Accepted:
November 15,
2014
Received in revised form:
November 10,
2014
Received:
September 19,
2014
Footnotes
☆Disclosure statement: The authors have nothing to disclose.
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
