Abstract
We describe how the combination of imaging and histologic findings was essential in
establishing a preoperative diagnosis of an extremely rare malignant granular cell
tumor (GrCT) occurring in the lower extremity of a 17-year-old man. Magnetic resonance
imaging demonstrated a large infiltrative tumor of heterogeneous intermediate signal
intensity on both T1- and T2-weighted sequences. Subsequent computed tomography (CT)
and fluorodeoxyglucose positron emission tomography CT scans of the patient revealed
distant nodal and skeletal metastases.
Keywords
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References
- Über myome, ausgehend von der quergestreiften willkürlichen muskulatur.Virchows Arch Pathol Anat. 1926; 260: 215-233
- Granular cell myoblastoma—a misnomer.Cancer. 1962; 15: 936-954
- Malignant granular cell tumor of soft tissue.Am J Surg Pathol. 1998; 22: 779-794
- Granular cell tumors of the extremities.Clin Orthop Relat Res. 2000; 380: 191-198
- Intramuscular granular cell tumor in the lower extremities.Clin Orthop Relat Res. 2010; 468: 1384-1389
- Intramuscular malignant granular cell tumor.Skeletal Radiol. 1997; 26: 116-121
- Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation.Skeletal Radiol. 2005; 34: 625-631
- Granular cell tumors of extremities.Clin Orthop Relat Res. 2006; 455: 267-273
- Granular cell tumor: a clinicopathologic study of 110 patients.J Surg Oncol. 1980; 13: 301-316
- Case report 820.Skeletal Radiol. 1994; 23: 63-66
- FDG PET-CT evaluation of granular cell tumour of the soft tissue.Clin Nucl Med. 2010; 35: 192-193
- Granular cell tumor.in: Soft tissue tumors. 4th ed. CV Mosby, St. Louis, MO2004: 1178-1187
- Diagnosis of malignant granular cell tumor metastatic to bone by fine needle aspiration cytology: a case report.Acta Cytol. 2010; 54: 190-192
- Metastatic granular cell tumor: a case report and review of the literature.Acta Oncol. 2006; 45: 91-94
- Immunohistochemical and molecular analysis of p53, MDM2, proliferating cell nuclear antigen and Ki67 in benign and malignant peripheral nerve sheath tumors.Virchows Arch. 1995; 427: 19-26
Article info
Publication history
Published online: November 18, 2014
Accepted:
November 11,
2014
Received in revised form:
November 7,
2014
Received:
September 30,
2014
Footnotes
☆The authors declare that they have no sources of support and no conflict of interest.
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
