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Hepatocellular adenoma showing high uptake of 18F-fluorodeoxyglucose (FDG) via an increased expression of glucose transporter 2 (GLUT-2)

  • Takaaki Nakashima
    Affiliations
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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  • Yukihisa Takayama
    Affiliations
    Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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  • Akihiro Nishie
    Correspondence
    Corresponding author. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan. Tel.: +81-92-642-5695; fax: +81-92-642-5708.
    Affiliations
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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  • Yoshiki Asayama
    Affiliations
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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  • Shingo Baba
    Affiliations
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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  • Youichi Yamashita
    Affiliations
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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  • Ken Shirabe
    Affiliations
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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  • Yuichiro Kubo
    Affiliations
    Department of Anatomic Pathology, Pathological Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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  • Tomoyuki Hida
    Affiliations
    Department of Anatomic Pathology, Pathological Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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  • Hiroshi Honda
    Affiliations
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka City, Fukuoka 812–8582, Japan
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      Abstract

      Hepatocellular adenoma (HCA) is a benign liver neoplasm composed of hepatocytes. We experienced HCA demonstrating a high uptake of 18F-fluorodeoxyglucose (FDG) on positron emission tomography–computed tomography, mimicking a malignant tumor. The mechanism underlying the uptake of FDG has not been identified. Here, we discuss that an enhancement of glucose metabolism via an increased expression of glucose transporter 2 may have a role in the high uptake of FDG shown by HCAs.

      Keywords

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